Journal: Journal of Pharmacy Research

Article Id: JPRS-QA-00001800
Title: Development, Validation and Stability Study of UV Spectrophotometric Method for Determination of Sofosbuvir in Bulk and Pharmaceutical Dosage Forms
Category: Quality Assurance
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The aim of this study was to develop a new, rapid and highly sensitive UV spectrophometer method for the Sofosbuvir bulk drug. The mobile phase consisted of Water & Ethanol in the ration of 60:40v/v and the wavelength to maximum absorbance at 260 nm. Analytical calibration curves were linear within a concentration range from 2 to 12μg/ml and coefficient of correlation 0.997. %RSD was found to be less than 2. The result of analysis has been validated statistically. This method will be validated in accordance with ICH requirements included the linearity, precision, accuracy sensitivity, and specificity. Hence the proposed method can be used for the reliable quantification of Sofosbuvir in tablet formulation.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Bhusnure Omprakash. G.*, Makanikar Vivek. G., Gholve Sachin B., Wale R. R., Poulkar Madhuri. V

    Affiliation(s) Name:

    Department of Quality Assurance, Channabasweshwar Pharmacy College
    Kava Road, Basweshwar Chowk, Latur, Maharashtra, India-413512

    *Corresponding author
    Somendra Kumar Maurya
    P.G. Scholar
    Department of Pharmaceutical Sciences,
    Shri Guru Ram Rai Institute of Technology & Science, Patel Nagar, Dehradun 248001, Uttarakhand, India

    Received on:14-05-2017; Revised on: 24-06-2017; Accepted on: 08-07-2017

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Bhusnure Omprakash. G.*, Makanikar Vivek. G., Gholve Sachin B., Wale R. R., Poulkar Madhuri. V

    Title:Development, Validation and Stability Study of UV Spectrophotometric Method for Determination of Sofosbuvir in Bulk and Pharmaceutical Dosage Forms
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (July)
    Year:2017
    Page No: (847-849)
  • Experimental Methods Keywords

    Methodology:UV Spectroscopy, Validation, Stress Studies
    Research Materials:Sofosbuvir

Keywords

Sofosbuvir UV Spectroscopy Validation Stress Studies

Our Services

Most Downloaded List