Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001847
Title: Age peculiarities of the blockade of α2 -adrenoceptors in the formation of the heart sympathetic innervations
Category: Pharmacology
Section: Research Article
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    Aim: α2-adrenoreceptors (ARs) in the heart of mammals modulate various regulatory effects. Located on the presynaptic membrane, α2-ARs regulate the release of noradrenaline and epinephrine from the nerve terminals. Wide expression of this type of ARs in various tissues and organs mediates various physiological and pharmacological effects in the cardiovascular system. α2-AR subtypes have been identified in the human myocardium based on pharmacological analysis and molecular cloning. Material and Methods: However, there are insufficient data on the study of the influence of this AR subtype in the cardiac regulation. The study involved a series of experiments with a α2-AR blockade by a specific blocker yohimbine. The experiments were performed on the striae of the myocardium of the right atrium and ventricles of rats of 3, 6, and 20 weeks of age. Results: The results obtained indicate that the α2-AR specific blockade reduces the contractile force of the atrial and ventricular myocardium striae of rats of 20 weeks of age. The 3-week-old rats had a reduced contractile force in the atria and a steady contractile force in the ventricles. In 6-week-old rats, the contractile force in the atria did not change but decreased in the ventricles. Conclusion: It is possible that during the formation of the sympathetic cardiac innervation, α2
    -ARs regulate the contractile function of the heart muscle only in some of its departments.

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    Author(s) Name:

    Anna Mikhailovna Kuptsova, Luiza Irekovna Khisamieva, Nafisa Ilgizovna Ziiatdinova*, Timur Lvovich Zefirov

    Affiliation(s) Name:

    Department of Man’s Health Protection, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia


    *Corresponding author: Nafisa Ilgizovna Ziiatdinova, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia. 

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    Author:

    Anna Mikhailovna Kuptsova, Luiza Irekovna Khisamieva, Nafisa Ilgizovna Ziiatdinova*, Timur Lvovich Zefirov

    Title:Age peculiarities of the blockade of α2 -adrenoceptors in the formation of the heart sympathetic innervations
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (Oct )
    Year:2017
    Page No: (1201-1204)
  • Experimental Methods Keywords

    Methodology: α2 -adrenoreceptors, Inotropy, Ontogenesis, Sympathetic cardiac innervation
    Research Materials:Age peculiarities

Keywords

α2 -adrenoreceptors Inotropy Ontogenesis Sympathetic cardiac innervation

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