Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000189
Title: Physalis peruviana Linn. fruit extract improves insulin sensitivity and ameliorates hyperglycemia in high-fat diet low dose STZ-induced type 2 diabetic rats
Category: Pharmacology
Section: Research Article
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    Physalis peruviana Linnaeus, belonging to the family Solanaceae and genus Physalis, possess a wide array of pharmacological properties. In the absence of systemic studies in the literature, the present study was aimed to explore the antidiabetic potential of the Physalis peruviana fruits in high fat diet fed-low dose STZ induced experimental type 2 diabetes in rats. Phytochemical screening of the fruit extract was performed. Diabetic rats were treated with Physalis peruviana fruit extract at a dosage of 200 mg/kg b.w daily for 30 days. Metformin (200 mg/kg. b.w) was used as a standard drug. The physiological criterions such as food and fluid intake were recorded. The levels of fasting blood glucose, plasma insulin and HbA1c were also estimated. Intraperitoneal insulin tolerance test was performed. The level of glycogen content in liver tissue was estimated. The activities of serum aspartate transaminase, alanine transaminase and alkaline phosphatase were assayed. The fruit extract supplementation attenuated the elevated levels of glucose, glycosylated hemoglobin, AST, ALT and ALP. The insulin level was improved with an improvement in hepatic glycogen content of insulin resistant diabetic rats. The fruit extract improves insulin sensitivity which is evident from intraperitoneal insulin tolerance test. These results showed that Physalis peruviana fruits are non toxic in nature and possess significant antidiabetic properties which might be attributed to the presence of biologically active ingredients present in the fruit extract.

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    Author(s) Name:

    M. Sathyadevi, E.R. Suchithra and S. Subramanian*

    Affiliation(s) Name:

    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India

    *Corresponding author.
    Dr. S. Subramanian
    Assistant Professor
    Department of Biochemistry
    University of Madras
    Guindy campus, Chennai – 600 025
    Tamilnadu, India

    Received on:26-03-2014; Revised on: 20-04-2014; Accepted on:21-04-2014

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    M. Sathyadevi, E.R. Suchithra and S. Subramanian*

    Title:Physalis peruviana Linn. fruit extract improves insulin sensitivity and ameliorates hyperglycemia in high-fat diet low dose STZ-induced type 2 diabetic rats
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (April)
    Page No: (625-632)
  • Experimental Methods Keywords

    Methodology:High fat diet fed streptozotocin induced diabetes,Toxicity and dosage fixation studies,Biochemical parameters
    Research Materials:Physalis peruviana


Physalis peruviana; Type 2 diabetes; high fat diet; Streptozotocin; antidiabetic

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