Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000196
Title: Synthesis of novel Triazolo Thienopyrimidine derivatives as antimicrobial agents – A physicochemical study
Category: Pharmaceutical Chemistry
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    In this study, a series of novel 2-Methyl-4-(1-methyl-1H-[1,2,3] triazol-4-yl-methoxy)-5,6,7,8-tetrahydra-benzo[4,5]thieno[2,3-d]pyrimidine derivatives (IVa-e) were synthesized by treating 2-Methyl/Phenyl-4-prop-2-ynyloxy-5,6,7,8-tetrahydro benzo[4,5] thieno [2,3-d] pyrimidine (IIIa/b) with alkyl azides in the presence of copper sulphate and dimethylsulphoxide. By treating 2-Methyl-5,6,7,8,-tetrahydrobenzo[b]thieno [2,3-d]pyrimidine-4-one(II) and its derivatives with propargyl bromide in the presence of potassium carbonate in acetone results in the formation of O-substituted compound-III and its derivatives. The compound-II and its derivatives were synthesized by treating 2-amino-thiophene -3-carboxylic acid ethyl ester (I) with alkyl/aryl nitrile in the presence of dry HCl and 1,4-dioxane. The newly synthesized compounds (IVa-e) were purified, separated, and characterized by TLC, IR, and Mass spectra. These representative analogues were screened for invitro antimicrobial activity. The compounds exhibited significant antibacterial and antifungal activities.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Srujana Muthadi1, Shirisha Thadishetti2, Mamatha Kasula*

    Affiliation(s) Name:

    1Department of Pharmacy, Chaitanya College of Pharmacy Education and Research, Warangal, A.P, India.
    2 Medicinal Chemistry Research Division, Vaagdevi College of Pharmacy, Hanamkonda, Warangal, A.P, India.
    *Department of Chemistry , Kakatiya University, Warangal-506009, Andhra Pradesh, India.



    *Corresponding author.
    Mamatha Kasula
    Department of Chemistry ,
    Kakatiya University, Warangal-506009,
    Andhra Pradesh, India


    Received on:18-04-2014; Revised on: 29-04-2014; Accepted on:05-05-2014

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Srujana Muthadi1, Shirisha Thadishetti2, Mamatha Kasula*

    Title:Synthesis of novel Triazolo Thienopyrimidine derivatives as antimicrobial agents – A physicochemical study
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (May)
    Year:2014
    Page No: (624-627)
  • Experimental Methods Keywords

    Methodology:synthesis, Antimicrobial activity
    Research Materials:novel Triazolo Thienopyrimidine derivatives

Keywords

Thieno pyrimidines dimethylsulphoxide Antimicrobial IC50 values.

Our Services

Most Downloaded List