Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00002008
Title: Preparation and characterization of lacidipine as an oral fast dissolving film
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background: Fast dissolving oral drug delivery system is solid dosage form which disintegrates or dissolves within second when placed in the mouth without need of water or chewing. In present investigation, an attempt has been made to develop oral fast dissolving film of calcium channel blocker lacidipine. Method: Five formulas were prepared by solvent casting method using HPMC (METOLOSE) ® as a film forming polymer and evaluated for their physical characteristics such as thickness, weight variation, folding endurance, drug content, disintegration time and in vitro drug release. The compatibility of the drug in the formulation was confirmed by FTIR and DSC studies. Result and Conclusion: The optimized formula F1 showed minimum in vitro disintegration time of 25 second and highest dissolution rate 97.3% in 10 minutes with good mechanical properties. Based on overall results, the conclusion that lacidipine was successfully prepared as oral fast dissolving film with accepted properties.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Nawal Ayash Rajab, Zainab E. Jassim*, Ahmed Majid Hameed

    Affiliation(s) Name:

    Department of Pharmaceutics, College of Pharmacy,  University of Baghdad, Baghdad, Iraq

    *Corresponding author: Zainab E. Jassim, Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Nawal Ayash Rajab, Zainab E. Jassim*, Ahmed Majid Hameed

    Title:Preparation and characterization of lacidipine as an oral fast dissolving film
    Journal:Journal of Pharmacy Research
    Vol(issue):12 (March)
    Year:2018
    Page No: (321-326)
  • Experimental Methods Keywords

    Methodology:Preparation , characterization
    Research Materials:Lacidipine

Keywords

Hydroxypropyl methylcellulose (METOLOSE) ® Lacidipine Oral films Solvent casting method

Our Services

Most Downloaded List