Journal: Drug Invention Today

Article Id: JPRS-pp-00002136
Title: Comparison of safety and effectiveness of ondansetron and domperidone in patients with gastrointestinal problems
Category: Pharmacy Practice
Section: Research Article
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    Objective: The objective of this study was to compare the safety and effectiveness of ondansetron and domperidone in patients with gastrointestinal (GI) problems. Materials and Methods: A prospective observational comparative study design was used with the help of data entry forms and regular ward round participation. The numeric scoring system was used to evaluate the efficacy assessment of ondansetron and domperidone in time interval 0–24 h. Results: The study was conducted in 100 patients. 50 patients were treated with ondansetron. 50 patients were treated with domperidone. 20% was suffering from peptic ulcer. 20% was suffering from GERD. 20% was suffering from duodenal ulcer. 30% was suffering from nonsteroidal anti-inflammatory drugs-induced ulcer. 10% was suffering from other GI problems. Conclusion: In the management of GI disturbance patients, ondansetron was found to be more effective than domperidone, and hence, it is considered better than domperidone as ondansetron shows better efficacy than domperidone.

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    Author(s) Name:

    N. Vetrivel 1 , D. Praveen2 , P. Ranadheer Chowdary2 , K. Elan Cheziyan3 , M. Vijey Aanandhi 3 *

    Affiliation(s) Name:

    1 Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India,

    2 School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India,

    3 Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. M. Vijey Aanandhi, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Chennai, Tamil Nadu, India.

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    Author:

    N. Vetrivel 1 , D. Praveen2 , P. Ranadheer Chowdary2 , K. Elan Cheziyan3 , M. Vijey Aanandhi 3 *

    Title:Comparison of safety and effectiveness of ondansetron and domperidone in patients with gastrointestinal problems
    Journal:Drug Invention Today
    Vol(issue):10 (March)
    Year:2018
    Page No: (343-346)
  • Experimental Methods Keywords

    Methodology:Gastrointestinal disturbances, Nonsteroidal anti-inflammatory drugs, observational comparative study design
    Research Materials:Ondansetron and domperidone

Keywords

Domperidone Gastrointestinal disturbances Nonsteroidal anti-inflammatory drugs Ondansetron Ulcer

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