Journal: Journal of Pharmacy Research
Title: Role of Leukotriene in Inflammation and Antileukotriene Therapy
Category: Pharmacology
Section: Review Article
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Abstract
The leukotrienes arise from oxidative metabolism of arachidonic acid through the action of the 5-lipoxygenase enzyme, leading to the unstable allylic epoxide leukotriene A4. This intermediate represents the substrate for two different specific enzymes, namely leukotriene A4-hydrolase and leukotriene C4-synthase, generating LTB4 and cysteinyl leukotrienes, respectively. LTC4 and LTD4 are potent contracting agents of smooth muscle in airways and blood vessels. LTB4 is known as a potent chemokinetic and chemotactic agent. A number of evidences reported in the literature underline the potential role of leukotrienes in the inflammatory responses that characterizes asthma and other pathological conditions. These potent lipid bioeffectors are synthesized during the course of inflammatory reactions and their pharmacological modulation is able to significantly attenuate the clinical manifestations associated with different inflammatory pathologies. Selective leukotriene inhibitors and receptor antagonists are currently under evaluation in the treatment of various inflammatory diseases.
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About the authors and Affiliations
Author(s) Name: Biren N. Shah*1, Nitin P. Patel1 and Priyanka Pandya1
Affiliation(s) Name: 1Vidyabharti Trust College of Pharmacy, Umrakh, Gujarat, India.
For correspondence:Biren N. Shah, 1Vidyabharti Trust College of Pharmacy, Umrakh, Gujarat, India.
E-mail: birenpharma@yahoo.co.in
Received on: 08-05-2008; Accepted on :22-09-2008-
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Author: Biren N. Shah*1, Nitin P. Patel1 and Priyanka Pandya1
Title: Role of Leukotriene in Inflammation and Antileukotriene Therapy Journal: Journal of Pharmacy Research Vol(issue): 1 (Oct-December 2008) Year: 2008 Page No: (113-135) -
Experimental Methods Keywords
Methodology: Inflammation and Antileukotriene Therapy Research Materials: Leukotriene
Keywords
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