Journal: Drug Invention Today
Title: Increased integrin and IKβ on the uterosacral ligament after childbirth
Category: Pharmacology
Section: Research Article
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Abstract
Background: Uterine prolapse is one manifestation of pelvic organs prolapse that characterized by the decline of the uterus from its original position as a result of the weakness of the pelvic floor buffer, especially sacrouterine and cardinal ligament. Objective: The objective of this study was to evaluate the level of integrin and IKβ expression on uterosacral ligament in women after vaginal delivery. Design: This was a cross-sectional study. Setting: Biomedical Laboratory. Patients and Methods: This research was conducted by collecting samples of biopsy uterosacral ligament from primigravida who underwent cesarean section after obstructive labor at Stage 1 and Stage 2 using consecutive sampling technique. Uterosacral ligaments of primigravida a term that has not entered labor phase and underwent elective cesarean section surgery were taken as control. Examination of Integrin and IKβ expression by immunohistochemistry. Main Outcome and Measures: Level of integrin and IKβ expression. Results: There were significant differences; mean of integrin activity in pregnant women has not been in labor group (92.8 ± 2.4%) compared to women in labor (95.99 ± 3.98%). There were significant differences between means of IKβ activity in pregnant group of women who never in labor (77.55 ± 6.77%) and group of pregnant women in labor (4:12 ± 93.59%). Conclusion: There were increased levels of integrin and IKβ in the uterosacral ligament of primigravida women in labor. There are increased levels of integrin and IKβ in the uterosacral ligament of primigravida women who underwent cesarean section due to obstructive labor at Stage 1 and Stage 2. Limitation: This study was not evaluated the level of nuclear factor kappa beta.
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About the authors and Affiliations
Author(s) Name: Rahajeng1,5*,Sanarto Santoso2,5, Hidayat Suyuti3,5, Tatit Nurseta4,5
Affiliation(s) Name: 1Urogynecology Division, Department of Obstetrics and Gynecology, Medical Faculty, Brawijaya University, Malang, Indonesia,
2Clinical Microbiology Department, Medical Faculty, Brawijaya University, Malang, Indonesia,
3Ophthalmology Department, Medical Faculty,Brawijaya University, Malang, Indonesia,
4Oncology Gynecology Division, Department of Obstetrics and Gynecology, Medical Faculty, Brawijaya University, Malang, Indonesia,
5Dr.Saiful Anwar Public Hospital, Malang, Indonesia.
*Corresponding author: Dr. Rahajeng, Department of Obstetrics and Gynecology, Division of Urogynecology, Saiful Anwar Hospital of Malang, Indonesia, Medical Faculty, Brawijaya University, Malang, Indonesia.
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Author: Rahajeng1,5*,Sanarto Santoso2,5, Hidayat Suyuti3,5, Tatit Nurseta4,5
Title: Increased integrin and IKβ on the uterosacral ligament after childbirth Journal: Drug Invention Today Vol(issue): 10 (July) Year: 2018 Page No: (1226-1230) -
Experimental Methods Keywords
Methodology: A cross-sectional study. Setting: Biomedical Laboratory Research Materials: Patients female
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