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Abstract

Aim: The purpose of the present research work is to formulate and characterize the microspheres of itraconazole and incorporation of microspheres in gel for topical drug delivery. Materials: Itraconazole, chitosan, liquid paraffin, Tween-20, gluteraldehyde, carbopol-450, triethanolamine. Methods: The chitosan microspheres were prepared by solvent evaporation method. The drug-excipient compatibility study of active drug (itraconazole) and polymer (chitosan) performed by Fourier transform-infrared spectroscopy and differential scanning calorimetry confirmed that there was no interaction. The resulting microspheres were evaluated for partial size, surface morphology, zeta potential, and microscopy of itraconazole microspheres. Formulation ICM-2 showed the maximum entrapment efficiency. Formulation ICM-2 was further used for the preparation of topical gel. Results: The formulation ICM-2 showed percent entrapment efficiency of 85.69 ± 0.64. Percent yield value was found to be 72% and drug loading efficiency 70%. The particle size was found 1.2113 µm and degree of swelling was found to be 45%. Conclusion: A sustained release pattern was obtained from the microsphere-based gel and the drug’s bioavailability was found to be enhanced. In vitro release study showed that itraconazole release from both kinds of microspheres was slow followed by an increase to reach a maximum of 96.332%.

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	JPR Solutions

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