Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002639
Title: Role of inflammatory cytokines in oral submucous fibrosis
Category: Pharmacology
Section: Research Article
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    Aims and Objectives: The objective of this case–control study was to evaluate the serum tumor necrosis factor-alpha (TNF-α) levels in the patients with oral submucous fibrosis (OSMF) and to determine the role of TNF-α in OSMF. Materials and Methods: Blood samples were collected from 30 patients who were diagnosed with OSMF and from 30 age- and sex-matched healthy participants. Serum was separated by centrifugation of blood samples in 2500 rpm for 10 min. TNF-α was estimated by enzyme-linked immunosorbent assay method. Results: The mean TNF-α level of study group and control group was 3.97 ± 2.57 and 16.83 ± 5.65, respectively. The difference between the TNF-α levels of these groups was statistically significant (P ≥ 0.000) according to the Student’s t-test. Conclusion: This study reveals that TNF-α level is increased in OSMF patients. That indicates TNF-α could play a key role in transformation of OSMF into malignancy.

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    Title:Role of inflammatory cytokines in oral submucous fibrosis
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Page No: (0-0)
  • Experimental Methods Keywords

    Methodology:Case–control study
    Research Materials: Inflammatory cytokines, Oral submucous fibrosis


Inflammatory cytokines Oral submucous fibrosis Tumor necrosis factor-alpha

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