Journal: Drug Invention Today

Article Id: JPRS-Pcol-00002641
Title: Evaluating the role of extracellular matrix molecules and enzymes in periodontitis
Category: Pharmacology
Section: Research Article
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    Introduction: Inflammation of the gums and supporting structures of the teeth are known as periodontitis. It is said to be one of the most common inflammatory diseases in the human oral cavity. This inflammatory condition is caused by certain bacteria (known as periodontal bacteria) and by the local inflammation triggered by those bacteria. The extracellular matrix (ECM) plays a vital role on bacterial adhesion and degradation of ECM, and it is caused by the acute and chronic inflammation induced by periodontitis pathogens. Aim: The aim of this case–control study was to compare patients with a healthy periodontium and patients affected by periodontitis, evaluating the occurrence of enzymes and ECM molecules in oral tissues. Materials and Methods: About six patients were divided into two groups as follows: one group with dental implants with a diagnosis of peri-implantitis and one control group with implants classified as being “healthy.” The glycoproteins and mucin content were estimated, and the enzymes, such as cathepsin D, were assayed.Results: In periodontitis patients, the glycoproteins and ECM enzymes are decreased compared to normal control group. Conclusion: The role of ECM molecules and enzymes in periodontitis was evaluated.

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    Author(s) Name:

    Fathima Bareera Rezvi, V. Vishnu Priya*, R. Gayathri

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

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    Author:

    Fathima Bareera Rezvi, V. Vishnu Priya*, R. Gayathri

    Title:Evaluating the role of extracellular matrix molecules and enzymes in periodontitis
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2362-2365)
  • Experimental Methods Keywords

    Methodology:Case–control study
    Research Materials:Antibodies, Enzymes

Keywords

Antibodies Enzymes Extracellular matrix Periodontitis Periodontium

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