Journal: Drug Invention Today

Article Id: JPRS-CPS-00002692
Title: In silico design, docking, and synthesis of 3-hydroxy-3- methylglutaryl-coenzyme A reductase inhibitors
Category: Chemistry and Parallel Synthesis
Section: Research Article
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    In the present work, the docking studies were performed for the proposed compounds against 3-hydroxy-3-methylglutaryl- coenzyme A (HMG-CoA) reductase. All the proposed compounds showed nice docking score. The synthesis serine compounds with azetidinone nucleus were carried out. These compounds were expected to show antihyperlipidemic activity from the literature review. The compounds prepared by refluxing serine with different substituted aldehydes give an intermediate Schiff bases (1a-1f) which on treatment with chloroacetyl chloride give substituted azetidinones (2a-2f). The structure of the compounds was confirmed by spectral data. The final synthesized compounds act as a potent HMG-CoA reductase inhibitor. Furthermore, the azetidinone nucleus serves as a synergist by inhibiting the cholesterol absorption from the intestine.

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    Author(s) Name:

    S. Arunkumar1 , N. Ramalakshmi 2 *, S. Banu Priya2 , B. Hemalatha2 , P. Mani Megalai 2 , K. Padma2 , S. Jayashree2

    Affiliation(s) Name:

    1 Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, Ajmaan, United Arab Emirates,

    2 Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India

    *Corresponding author: N. Ramalakshmi, Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India.

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    Author:

    S. Arunkumar1 , N. Ramalakshmi 2 *, S. Banu Priya2 , B. Hemalatha2 , P. Mani Megalai 2 , K. Padma2 , S. Jayashree2

    Title:In silico design, docking, and synthesis of 3-hydroxy-3- methylglutaryl-coenzyme A reductase inhibitors
    Journal:Drug Invention Today
    Vol(issue):10 (December)
    Year:2018
    Page No: (2568-2571)
  • Experimental Methods Keywords

    Methodology:In silico design, docking, and synthesis
    Research Materials:3-hydroxy-3- methylglutaryl-coenzyme A reductase inhibitors

Keywords

: Azetidinone Cholesterol Hydroxy-3-methylglutaryl-coenzyme A reductase Serine

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