Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Ph-0000288
Title: Formulation, optimization and evaluation of fast disintegrating tablet of hydrochlorothiazide
Category: Pharmaceutics
Section: Research Article
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    The present study was aimed towards formulation and development of fast disintegrating tablet of hydrochlorothiazide by direct compression method using three different super disintegrating agents. The absorption rate of hydrochlorothiazide is 50-60% and the drug undergoes hepatic metabolism, so the attempt has been made to administer it as fast disintegrating tablet to increase it’s oral bioavailability. Fast disintegrating tablet was formulated using three different super disintegrants in the concentration of 3%, 4 % and 8% alone or in combination of super disintegrants. The formulation is optimized for the concentration of super disintegrants to give minimum disintegrating time with maximum drug release profile. Disintegration time, % friability and In vitro drug release were taken as the basis to optimize the fast disintegrating tablet. On the basis of results of preliminary batches, the formulation H5 containing crospovidone and croscarmellose were selected as independent variables for the 32 full factorial design as it shows less disintegration time with less percentage of friability. A 32 full factorial design was used to study the effect of croscarmellose sodium and crospovidone on disintegration time, % friability and In-vitro drug release. The responses were analyzed using ANOVA and by the polynomial equation, it was found that the concentration of croscramellose sodium and crospovidone significantly affects disintegration time and % friability. Optimized formulation H8 containing crospovidone (6%) and croscarmellose sodium (4%) showed the faster disintegration time (5 to 6 sec), less friability (0.35%) and increased % drug release (99.22% in 30 mins) as compared to other formulations. From the results of 32 full factorial design it can be concluded that crospovidone and croscarmellose sodium in combination is having better disintegrating property than alone or in combination with sodium starch glycolate. Formulation H8 containing 6% crospovidone and 4% croscarmellose sodium gives better disintegration and dissolution profile. Thus combination of crospovidone and croscarmellose sodium can be successfully used in the formulation of fast disintegrating tablets.

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  • About the authors and Affiliations

    Author(s) Name:

    Naisarg D. Pujara*, Ramesh B. Parmar

    Affiliation(s) Name:

    Department of Pharmaceutics, S. J. Thakkar Pharmacy College, Kalawad Road, Rajkot – 360005, Gujarat, India.

    *Corresponding author.
    Naisarg D. Pujara
    Department of Pharmaceutics,
    S. J. Thakkar Pharmacy College,
    Kalawad Road, Rajkot – 360005, Gujarat, India.


    Received on:12-01-2013; Revised on: 08-02-2013; Accepted on:26-02-2013

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    Author:

    Naisarg D. Pujara*, Ramesh B. Parmar

    Title:Formulation, optimization and evaluation of fast disintegrating tablet of hydrochlorothiazide
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (March)
    Year:2013
    Page No: (321-329)
  • Experimental Methods Keywords

    Methodology: Formulation, optimization and evaluation
    Research Materials:Crospovidone, Croscarmellose sodium,

Keywords

Crospovidone Croscarmellose sodium Fast disintegrating tablets Hydrochlorothiazide Sodium starch glycolate.

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