Journal: Drug Invention Today
Title: Evaluation of in vivo rheumatoid arthritis activity of polyherbal ethanolic extract containing formulations for selected potential Indian herbs
Category: Pharmaceutics
Section: Research Article
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Abstract
Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure for this disease. The present study was commenced to evaluate the in vivo antiarthritic effect of the polyherbal formulation of selected plants Polygonum glabrum, Canthium dicoccum, Ochna obtusata, and Argyreia nervosa. Materials and Methods: In vivo antiarthritic activity of the ethanolic extract of two different formulations containing the 400 mg/kg orally and 800 mg/kg body weight. Was assessed using turpentine oil and formaldehyde induced arthritis and complete Freund’s adjuvant-induced arthritis. Results: In turpentine oil, formaldehyde, and complete Freund’s adjuvant-induced arthritis models, the polyherbal extract formulations significantly (P < 0.001) reduced joint and paw swelling and markedly improved body weight, hematology profile, and parameters in complete Freund’s adjuvant model. Conclusion: It could be concluded that the ethanolic extract of two different formulations holds antiarthritic potential, supporting its traditional use in the treatment of RA.
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Author(s) Name: S. Jaya Kumari, V. Satyanarayana*
Affiliation(s) Name: Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India
*Corresponding author: V. Satyanarayana, Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Chennai, Tamil Nadu, India.
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Author: S. Jaya Kumari, V. Satyanarayana*
Title: Evaluation of in vivo rheumatoid arthritis activity of polyherbal ethanolic extract containing formulations for selected potential Indian herbs Journal: Drug Invention Today Vol(issue): 11 (January) Year: 2019 Page No: (11-17) -
Experimental Methods Keywords
Methodology: In vivo rheumatoid, Freund’s adjuvant-induced arthritis Research Materials: Polygonum glabrum, Canthium dicoccum, Ochna obtusata, Argyreia nervosa, Polyherbal, Ethanolic extract,
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