Journal: Journal of Pharmacy Research
Title: Formulation and in vitro evaluation of niosome encapsulated acyclovir
Category: Pharmaceutics
Section: Research Article
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Abstract
Acyclovir entrapped niosomes were prepared by hand shaking and ether injection process with different ratios of (1:1, 1;2 and 1:3) cholesterol (CHOL) and Span-80 (Non-ionic surfactant).The niosomes prepared were in the size range of 0.5- 5 microns in the case of hand shaking process and 0.5-2.5 microns in the case of Ether injection process. The order of encapsulation efficiency increases when span-80 concentration was increased. In-vitro release study on acyclovir niosomes indicates 76.64% release for formulation prepared with CHOL: Span-80 (1:1) and it takes an extended period of 1 day and 16 h for release.
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About the authors and Affiliations
Author(s) Name: Manivannan Rangasamy*, Balasubramaniam Ayyasamy,
Senthilkumar Raju1,Sandeep Gummadevelly2 and Sanaullah Shaik2
Affiliation(s) Name: 1Department of Pharm.Chemistry, Swamy Vivekanandha College of pharmacy, Elayampalayam, Namakkal, Tamilnadu, India.
2Department of Pharmaceutics, J.K.K.M.M.R.F, College of Pharmacy, B.Komarapalayam, Pin Code: 638 183, Namakkal, Tamilnadu, India.
For correspondence:
Manivannan Rangasamy, Dept.of Pharmaceutics, JKKMMRF’s college of Pharmacy, B.
Komarapalayam, Namakkal, Tamilnadu, India.
E-mail: manivannan_biotech@yahoo.co.in
Received on: 10-07-2008; Accepted on :02-10-2008-
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Author: Manivannan Rangasamy*, Balasubramaniam Ayyasamy,
Senthilkumar Raju1,Sandeep Gummadevelly2 and Sanaullah Shaik2
Title: Formulation and in vitro evaluation of niosome encapsulated acyclovir Journal: Journal of Pharmacy Research Vol(issue): 1 (Oct-December 2008) Year: 2008 Page No: (163-166) -
Experimental Methods Keywords
Methodology: Niosomes, Hand-Shaking process, Ether Injection process,VESICLE SIZE DETERMINATION Research Materials: Acyclovir
Keywords
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