Journal: Drug Invention Today
Title: Antioxidant activity of mangosteen peel (Garcinia mangostana L.) extracted using different solvents at the different times
Category: Pharmaceutics
Section: Research Article
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Abstract
Background: Extraction is conducted to extract the important compounds in mangosteen peel using solvents at the different time. Extraction time needs to be calculated so that the bioactive compound can be extracted optimally using the most efficient solvent. The extraction of mangosteen peel was conducted by soaking in solvent at particular time (1-2 days in general) without heating. Aim: This study aims to evaluate the effect of different solvents and maceration time on antioxidant activity of mangosteen peel extract. Materials and Methods: The present research was conducted by extracting mangosteen peel using ethanol (EtOH), acetone (Ace), ethyl acetate (EtOAc), methanol (MetOH), hexane (HX), acetic acid (AcetAc) and aquadest (Aqua) at 24, 36 and 48h. Antioxidant activity was examined using visible UV spectrophotometer at the particular wavelength. Result and Discussion: The result showed that the type of solvent and extraction time significantly (P<0.01) affected antioxidant activity. Acetone extract of mangosteen peel is the most optimal solvent for antioxidant activity in extraction time for 24 hours (IC50 = 9,468 + 0,324 ppm). A further test was required to obtain a better result using HPLC method. Conclusion: It was evidenced that the properties of solvents, particularly polarity index and time, significantly affected antioxidant activity.
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About the authors and Affiliations
Author(s) Name: Andri Kusmayadi 1,2 *, Lovita Adriani 1 , Abun Abun1 , Muchtaridi Muchtaridi 3 , Ujang Hidayat Tanuwiria1
Affiliation(s) Name: 1 Department of Animal Science, Faculty of Animal Science, Universitas Padjadjaran, Sumedang, Indonesia,
2 Department of Animal Science, Faculty of Agriculture, Universitas Perjuangan, Tasikmalaya, Indonesia,
3 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia
*Corresponding author: Andri Kusmayadi, Department of Animal Science, Universitas Perjuangan, Tasikmalaya, Indonesia.
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Author: Andri Kusmayadi 1,2 *, Lovita Adriani 1 , Abun Abun1 , Muchtaridi Muchtaridi 3 , Ujang Hidayat Tanuwiria1
Title: Antioxidant activity of mangosteen peel (Garcinia mangostana L.) extracted using different solvents at the different times Journal: Drug Invention Today Vol(issue): 11 (January) Year: 2019 Page No: (44-48) -
Experimental Methods Keywords
Methodology: Antioxidant activity,Maceration time Research Materials: Mangosteen peel extract,(Garcinia mangostana L
Keywords
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