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Abstract

Aim: The aim of this research to evaluate the activities of Zingiber zerumbet ethanolic extract (ZZEE) and Channa striata powder (CSP) used an animal model, albino Wistar mice, induced by alloxan; meanwhile, anti-inflammatory activity was induced using carrageenan to produce paw edema. Materials and Methods: The study used a post-test design with five treatment groups, each of which consisted of five mice. The groups for anti-inflammation study were negative control, positive control, 150 mg/kgBW dose of CSP, 150 mg/kgBW dose of ZZEE, and 150 mg/kgBW dose of the combination of CSP-ZZEE. The treatment groups of antidiabetic study were as negative control, positive control, 300 kg/kgBW dose of ZZEE, 300 mg/kgBW dose of CSP, and 300 mg/kgBW dose of the combination of ZZEE and CSP. Results: The results showed the percentage inhibition of the paw edema of ZZEE, CSP, combination of ZZEE-CSP, and positive control groups at 40.01 ± 7.19, 35.25 ± 8.48, 36.56 ± 7.22, and 36.10 ± 2.89%, respectively, whereas the percentage of decreasing capability of blood sugar level of ZZEE, CSP, combination of ZZE-CSP, and positive control successively was at 61.09 ± 16.20, 33.78 ± 26.67, 69.59 ± 13.53, and 74.72 ± 9.90%. Conclusions: There was a synergistic effect on anti-diabetes activity of ZZEE and CSP. Meanwhile in anti-inflammation study did not perform synergistic effect.

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	JPR Solutions

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