Journal: Drug Invention Today

Article Id: JPRS-P col-00003176
Title: Epigenetics and cancer
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    The activation of oncogenes and/or the deactivation of tumor suppression genes involve uncontrolled cell growth which leads to the development of cancer. Downregulation of cell adhesion receptors necessary for tissue-specific, cell-cell attachment, as well as upregulation of receptors that enhance cell motility, is required for metastasis. These characteristics can be modified by epigenetic changes including histone modifications, DNA methylation, and DNA hydroxymethylation. Signaling pathways that regulate apoptosis and autophagy, as well as microRNA, include targets for these epigenetic changes. Predisposed normal cells change to cancer progenitor cells that, after growing, experience an epithelial-mesenchymal transition. Epigenetic medication seems to enhance the action of traditional medicine, usually by demethylating and reexpressing tumor suppressor genes to inhibit tumorigenesis. Adopting epigenetic alteration as a brand new hallmark of cancer could be a logical and necessary step that may additionally encourage the event of novel epigenetic biomarkers and therapeutics.

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    Author(s) Name:

    Yamini Meshram1 , Suman K. Ray2 *

    Affiliation(s) Name:

    1 Department of Biochemistry and Biotechnology, Dr. Ambedkar College, Deekshabhoomi, Nagpur, Maharashtra, India,

    2 Department of Life Science, PTC College, Vinayaka Mission University Study Centre, Kolkata, West Bengal, India

    *Corresponding author: Suman K. Ray, Department of Life Science, PTC College, Vinayaka Mission University Study Centre, Kolkata - 700012, West Bengal, India.

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    Author:

    Yamini Meshram1 , Suman K. Ray2 *

    Title:Epigenetics and cancer
    Journal:Drug Invention Today
    Vol(issue):12 (February)
    Year:2019
    Page No: (265-268)
  • Experimental Methods Keywords

    Methodology:Apoptosis, Cancer, Demethylation, Epigenetics, Epithelial-mesenchymal transition, Hydroxymethylation, Metastasis, Methylation, MicroRNA, Therapeutics
    Research Materials:Apoptosis, Cancer

Keywords

Apoptosis Cancer Demethylation Epigenetics Epithelial-mesenchymal transition Hydroxymethylation Metastasis Methylation MicroRNA Therapeutics

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