Journal: Drug Invention Today
Title: Effect of chebulagic acid on apoptotic regulators in prostate cancer cell line - PC-3
Category: Pharmaceutics
Section: Research Article
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Abstract
Background: Prostate cancer (PCa) is the second most typical cancer and also the sixth leading reason behind cancer death among men worldwide with associate degree calculable recorded amount of 1.1 million cases and 307,000 deaths in 2012. Chebulagic acid (CA), a benzopyran tannin, is one of the major bioactive compounds present in the fruits of Terminalia chebula. Aim: The present study was aimed at assessing the effects of CA on proapoptotic (Bax) and antiapoptotic protein molecules such as B-cell lymphoma-2 (Bcl-2) and Bcl-extra large (Bcl-xl) in PC-3 cell line. Materials and Methods: Antiproliferative potential of CA was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. PC-3 cells were treated with different concentration of CA (1, 5, 10, 25, 50, and 100 µM). Pro- and anti-apoptotic proteins were done by western blotting methods. PC-3 cells were treated with the treatment of CA resulted in a dose-dependent inhibition of the growth of PC-3 cells. This was associated with increased levels of proapoptotic protein (Bax) and the reduced levels of the antiapoptotic proteins Bcl-2 and Bcl-xL. Conclusion: The present findings clearly suggest that CA induces apoptosis by the regulating intrinsic pathways which could be very useful for the treatment of PCa.
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About the authors and Affiliations
Author(s) Name: R. Ponnulakshmi1, B. Shyamaladevi2 ,J. Selvaraj2*, G.Valli1, V. Purushothaman1 , Murad Alsawalha3 , Surapaneni Krishna Mohan4
Affiliation(s) Name: 1Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India,
2 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,
3 Department of chemical and Process Engineering, Technology, Jubail Industrial College, Jubail Industrial City, Saudi Arabia,
4 Department of Biochemistry, Chetinad Hospital and Research Institute, Chetinad Academy of Research and Education, Chennai, Tamil Nadu, India.
*Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Savvehtha University, Chennai - 600 077, Tamil Nadu, India.
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Author: R. Ponnulakshmi1, B. Shyamaladevi2 ,J. Selvaraj2*, G.Valli1, V. Purushothaman1 , Murad Alsawalha3 , Surapaneni Krishna Mohan4
Title: Effect of chebulagic acid on apoptotic regulators in prostate cancer cell line - PC-3 Journal: Drug Invention Today Vol(issue): 12 (February) Year: 2019 Page No: (281-285) -
Experimental Methods Keywords
Methodology: Apoptosis, B-cell lymphoma-2 Research Materials: Terminalia chebula, Chebulagic acid
Keywords
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