Journal: Drug Invention Today
Title: Effect of chebulagic acid on apoptotic regulators in prostate cancer cell line - PC-3
Category: Pharmaceutics
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
Background: Prostate cancer (PCa) is the second most typical cancer and also the sixth leading reason behind cancer death among men worldwide with associate degree calculable recorded amount of 1.1 million cases and 307,000 deaths in 2012. Chebulagic acid (CA), a benzopyran tannin, is one of the major bioactive compounds present in the fruits of Terminalia chebula. Aim: The present study was aimed at assessing the effects of CA on proapoptotic (Bax) and antiapoptotic protein molecules such as B-cell lymphoma-2 (Bcl-2) and Bcl-extra large (Bcl-xl) in PC-3 cell line. Materials and Methods: Antiproliferative potential of CA was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. PC-3 cells were treated with different concentration of CA (1, 5, 10, 25, 50, and 100 µM). Pro- and anti-apoptotic proteins were done by western blotting methods. PC-3 cells were treated with the treatment of CA resulted in a dose-dependent inhibition of the growth of PC-3 cells. This was associated with increased levels of proapoptotic protein (Bax) and the reduced levels of the antiapoptotic proteins Bcl-2 and Bcl-xL. Conclusion: The present findings clearly suggest that CA induces apoptosis by the regulating intrinsic pathways which could be very useful for the treatment of PCa.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: R. Ponnulakshmi1, B. Shyamaladevi2 ,J. Selvaraj2*, G.Valli1, V. Purushothaman1 , Murad Alsawalha3 , Surapaneni Krishna Mohan4
Affiliation(s) Name: 1Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India,
2 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,
3 Department of chemical and Process Engineering, Technology, Jubail Industrial College, Jubail Industrial City, Saudi Arabia,
4 Department of Biochemistry, Chetinad Hospital and Research Institute, Chetinad Academy of Research and Education, Chennai, Tamil Nadu, India.
*Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Savvehtha University, Chennai - 600 077, Tamil Nadu, India.
-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: R. Ponnulakshmi1, B. Shyamaladevi2 ,J. Selvaraj2*, G.Valli1, V. Purushothaman1 , Murad Alsawalha3 , Surapaneni Krishna Mohan4
Title: Effect of chebulagic acid on apoptotic regulators in prostate cancer cell line - PC-3 Journal: Drug Invention Today Vol(issue): 12 (February) Year: 2019 Page No: (281-285) -
Experimental Methods Keywords
Methodology: Apoptosis, B-cell lymphoma-2 Research Materials: Terminalia chebula, Chebulagic acid
Keywords
Our Services
- Complications of diabetes mellitus: A review
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Design, Evaluation, Parameters and Marketed Products of transdermal patches: A Review
- Effects of audio-visual aids on convincing patients for dental treatment – A review
- In-vitro anti-arthritic activity of Abutilon indicum (Linn.) Sweet
- Awareness of effects of sleep deprivation among college students
- Biodegradable plastic production from corn starch
- Studies on antifungal properties of Talisadi Churna on human pathogens
- Awareness of selfie addiction among teenagers: A questionnaire-based study
- Analysis of Amino Acids By Paper Chromatography
- A review on cellulose and its utilization from agro‑industrial waste
- Application of nanotechnology for Ayurvedic drugs and formulations
- Comparative study on clove and garlic on relieving tooth pain
- Plant natural products: Their pharmaceutical potential against disease and drug resistant microbial pathogens
- Preliminary phytochemical screening and HPTLC fingerprinting of Nicotiana tabacum leaf
- Hypovolemic shock - A review
- Review On: Fast Dissolving Tablet
- QbD Approach for Analytical Method Development and Validation of Melatonin by spectroscopic Method
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Soxhlet Extraction of Neem seed (Azadirachta indica A. Juss) Using Hexane as a Solvent.
- Formulation and evaluation of Aloe vera gels
- Current Trends in Herbal Medicines
- A comparative study of pregabalin and gabapentin combinations in type 2 diabetic neuropathy patients
- Pharmacognostic Study Of Plant Euphorbia hirta L
- Hibiscus rosa sinensis Linn – ‘‘Rudrapuspa’’ : A Review
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- Sleep deprivation and cell phone usage among teenagers
- A Comparative study on Antioxidant, Proximate analysis, Antimicrobial activity and phytochemical analysis of Aloe vera and Cissus quadrangularis by GC-MS
- GC-MS study and phytochemical profiling of Mimosa pudica Linn.
- Preparation of intranasal pregabalin microspheres: In vitro, ex vivo and in vivo pharmacodynamic evaluation