Journal: Drug Invention Today

Article Id: JPRS-P col-00003184
Title: The role of gingival gelatinases and salivary collagenases in the periodontal conditions
Category: Pharmaceutics
Section: Review Article
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    This review focuses specifically on gingival gelatinases and salivary collagenases which are matrix metalloproteinases (MMPs) and their role in the periodontal conditions. A group of enzymes capable of degrading almost all extracellular matrix proteins, MMPs, contribute to both normal and pathological tissue remodeling. The expression of different MMPs has been reported in different stages of periodontal conditions. MMPs have been identified in pulpal and periapical inflammation and are strongly correlated with periodontal diseases since they are the major players in collagen breakdown during periodontal tissue destruction. The use of MMP inhibitors could help the prevention and treatment of many MMP-related oral diseases. This review summarizes the basic knowledge on periodontal diseases and the role of MMPs for the development of periodontal diseases.

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    Author(s) Name:

    Adithya R. Pillai, R. Ponnu Lakshmi, V. Purushothaman*, K. Vinothkumar

    Affiliation(s) Name:

    Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. V. Purushothaman, Meenakshi Academy of Higher Education and Research, MAHER University, Chennai - 600 078, Tamil Nadu, India.

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    Author:

    Adithya R. Pillai, R. Ponnu Lakshmi, V. Purushothaman*, K. Vinothkumar

    Title:The role of gingival gelatinases and salivary collagenases in the periodontal conditions
    Journal:Drug Invention Today
    Vol(issue):12 (February)
    Year:2019
    Page No: (298-302)
  • Experimental Methods Keywords

    Methodology:Periodontitis
    Research Materials: Collagenases, Gelatinases

Keywords

Collagenases Gelatinases Matrix metalloproteinases Periodontitis

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