Journal: Drug Invention Today

Article Id: JPRS-P col-00003187
Title: Estrogen deficiency during menopause and its management: A current update
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    Different phases of a woman’s life: Puberty, menses, pregnancy, and menopause have varied influence on her oral health. During the menopause, women go through biological and endocrine changes, particularly in their sex steroid hormone production, affecting their health. Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogens receptor regulate various aspects of glucose and lipid metabolism. Disturbances of this metabolic signal lead to the development of metabolic syndrome and a higher cardiovascular risk in woman. The absence of estrogens is a clue factor in the onset of cardiovascular disease during the menopausal period, which is characterized by lipid profile variations and predominant abdominal fat accumulation. However, influence of the absence of these hormones and its relationship to higher obesity in women during menopause is not clear. This systematic review discusses of the role of estrogens and estrogen receptors in adipocyte differentiation and its various effects and brief discussion on its management.

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    Author(s) Name:

    V. T. Hemalatha1 , A. Julius2 , S. P. Kishore Kumar3 , L. Vijayalakshmi 4 , Shankar Narayanan1

    Affiliation(s) Name:

    1 Department of Oral Medicine and Radiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, Chennai, Tamil Nadu, India,

    3 Department of Orthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education And Research, Pallikaranai, Chennai, Tamil Nadu, India,

    4 Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India

    *Corresponding author: Dr.V.T. Hemalatha Mds., Phd Research Scholar, Associate Professor, Department of Oral Medicine and Radiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, Chennai-600100,India.

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    Author:

    V. T. Hemalatha1 , A. Julius2 , S. P. Kishore Kumar3 , L. Vijayalakshmi 4 , Shankar Narayanan1
    Title:Estrogen deficiency during menopause and its management: A current update
    Journal:Drug Invention Today
    Vol(issue):12 (February)
    Year:2019
    Page No: (314-320)

  • Experimental Methods Keywords

    Methodology:Menopause, A current update
    Research Materials:Estrogen hormone (estrogens/progestogens)

Keywords

Estrogen hormone (estrogens/progestogens) replacement therapy Menopause Weight gain

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