Journal: Drug Invention Today

Article Id: JPRS-P col-00003203
Title: Interactions of some intracellular Hyalomma asiaticum pathogens in organism
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of this study was to study the interaction of intracellular pathogens of tick-borne encephalitis (TBE) and salmonella in Hyalomma asiaticum tick body during the bloodsucking of imago and nymphs on laboratory animals with viremia and bacteremia. With a simultaneous infection from H. asiaticum ticks by two intracellular pathogens (CE and salmonella virus), the virus titer decreases after 30–40 days, and then, the ticks die. Materials and Methods: The study was conducted on the ticks of a laboratory line, free from pathogenic flora. Tick encephalitis virus was used to infect ticks with the “Sofin” strain and the bacterial culture Salmonella typhimurium LT-2. Results: During an infection of nymphs, H. asiaticum virus persisted in their body for the entire observed period, both at the infection of nymphs with a mixed infection and at the infection with TBE virus. Salmonella persisted in the body of sexually mature H. asiaticum ticks with a mixed infection up to 12 days. Conclusions: With a mixed infection of ticks by two infection pathogens at the same time (TBE and salmonella virus), the inhibition of both TBE and salmonella virus growth and development takes place.

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    Author(s) Name:

    V. M. Podboronov1 *, I. P. Smirnova2 , O. M. Kuznetsova2 , I. V. Podoprigora2 , S. P. Syatkin2 , A. S. Botin2 , E. V. Neborak2 , M. K. Nurmuradov2

    Affiliation(s) Name:

    1 Fеdерal State Budgetary Institution “National Research Center fоr Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation, 123098, Russian Federation,

    2 Department of Medical Institute, Peoples’ Friendship University of Russia, RUDN University, Moscow, 117198, Russian Federation

    *Corresponding author: V.M. Podboronov, Fеdерal State Budgetary Institution “National Research Center fоr Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya” of the Ministry of Health of the Russian Federation, 18 Gamaleya Street, Moscow, 123098, Russian Federation.

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    Author:

    V. M. Podboronov1 *, I. P. Smirnova2 , O. M. Kuznetsova2 , I. V. Podoprigora2 , S. P. Syatkin2 , A. S. Botin2 , E. V. Neborak2 , M. K. Nurmuradov2

    Title:Interactions of some intracellular Hyalomma asiaticum pathogens in organism
    Journal:Drug Invention Today
    Vol(issue):11 (March)
    Year:2019
    Page No: (517-520)
  • Experimental Methods Keywords

    Methodology:Bacterial Culture
    Research Materials:Borrelia, Hyalomma asiaticum, Salmonella, Tick-borne encephalitis

Keywords

Borrelia Hyalomma asiaticum Salmonella Tick-borne encephalitis

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