Journal: Journal of Pharmacy Research
Title: Pseudomonas aeruginosa vaccine - Search for cell surface-exposed proteins as a subunit vaccine candidate by reverse vaccinology approach
Category: Pharmaceutical Biotechnology
Section: Research Article
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Abstract
Aim: Development of a vaccine to fight Pseudomonas aeruginosa infections is of prime concern as the pathogen has developed multiple drug resistance. In the present study, by reverse vaccinology approach, a number of cell surface-exposed proteins are reported as potential vaccine candidate. Materials and Methods: P. aeruginosa PA 38182 encoded 7279 proteins were screened as cell surface proteins using TMHMM, LipoP, PsortB, and Signal P server. 40 screened antigens were selected and screened for suitability as epitope candidates by human leukocyte antigen Pred epitope prediction server. Results: A total of 30 high score epitopes were recorded; amongst them based on binding energy calculation, protein “putative holin” epitope emerged as the most suitable candidate. Conclusion: P. aeruginosa PA 38182 encodes 30 cell surface-exposed epitopes which could be implemented in vaccine research to control P. aeruginosa infections successfully since no approved vaccine is available for them.
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About the authors and Affiliations
Author(s) Name: Rajni Mishra1 , Dilip Gore2* , Avinash Upadhyay1
Affiliation(s) Name: 1 Hislop School of Biotechnology, Civil lines, Nagpur, Maharashtra, India,
2 Department of Biotechnology, Sai Biosystems Private Limited, Nagpur, Maharashtra, India
*Corresponding author: Dilip Gore, Sai Biosystems Private Limited Plot 271 Raghuji Nagar, Nagpur – 440009, Maharashtra, India
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Author: Rajni Mishra1 , Dilip Gore2* , Avinash Upadhyay1
Title: Pseudomonas aeruginosa vaccine - Search for cell surface-exposed proteins as a subunit vaccine candidate by reverse vaccinology approach Journal: Journal of Pharmacy Research Vol(issue): 13 (March ) Year: 2019 Page No: (36-39) -
Experimental Methods Keywords
Methodology: Antigen, Bioinformatics, Epitope, Reverse vaccinology Research Materials: Vaccine
Keywords
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