Journal: Drug Invention Today

Article Id: JPRS-P col-00003343
Title: A study on antioxidant activity, phenol, and flavonoid content of seedpod of Nelumbo nucifera Gaertn.
Category: Pharmaceutics
Section: Research Article
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    Objective: The objective of the present study was to evaluate the presence of phenol, flavonoid, tannin, antioxidant activity, and high-performance liquid chromatography (HPLC) analysis of quercetin (active component of Nelumbo nucifera [NN]) in ethanolic extract of the seedpod of Nelumbo nucifera (NNE). Materials and Methods: Preliminary screening of NNE was done for the presence of phenol, flavonoid, tannin, qualitatively, and quantitatively. Antioxidant activities of the NNE were estimated using extracts of aqueous, acetone, ethanol, and chloroform by in vitro antioxidant assays such as 1,1-diphenyl-2- picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Results: Total phenolic content in NNE was 93.45 mg gallic acid equivalents, the total flavonoid content was 295.312 mg/g quercetin equivalents in NNE, and tannin content is 508.7 mg/g tannin equivalents in NNE. The NNE was evaluated for antioxidant activities by DPPH and FRAP assays. Among the different solvent, the ethanolic extract recorded the most effective DPPH radical scavenging activity (69.2%) and FRAP value was 21.52 µm. The results of HPLC analysis revealed the presence of active principle, namely quercetin. Conclusion: It can be concluded that NNE can be used as a potent natural antioxidant to overcome oxidative stress-induced diseases.

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    Author(s) Name:

    P. N. Ruvanthika1 , S. Manikandan2 *

    Affiliation(s) Name:

    1Department of Physiology, Tagore Medical College and Hospitals (Research Scholar, PhD in Bharath University), Affiliated to TN Dr. MGR Medical University, Chennai, Tamil Nadu, India,

    2 Department of Physiology, Tagore Medical College and Hospitals, Affiliated to TN Dr. MGR Medical University, Chennai, Tamil Nadu, India

    *Corresponding author: S. Manikandan, Department of Physiology, Tagore Medical College and Hospitals, Affiliated to TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.

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    Author:

    P. N. Ruvanthika1 , S. Manikandan2 *

    Title:A study on antioxidant activity, phenol, and flavonoid content of seedpod of Nelumbo nucifera Gaertn.
    Journal:Drug Invention Today
    Vol(issue):11 (April)
    Year:2019
    Page No: (835-840)
  • Experimental Methods Keywords

    Methodology:Antioxidant activity, Ferric-reducing antioxidant power
    Research Materials:seedpod of Nelumbo nucifera Gaertn.

Keywords

1 1-Diphenyl-2-picrylhydrazyl Antioxidant activity Ferric-reducing antioxidant power Nelumbo nucifera Phenol and flavonoid

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