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Abstract

Globally, the prevalence of chronic non-communicable diseases is increasing at an alarming rate, propelling the upsurge in cases of diabetes is the growing prevalence of obesity. Most patients who are type 2 diabetic are obese, and the global epidemic of obesity largely explains the dramatic increase in the incidence and prevalence of type 2 diabetes over the past 20 years. Improved understanding will help advance identification and development of effective treatment options and how future research in these areas might be directed to benefit prevention, interventions, and overall patient care. Recent studies have identified “links” between obesity and type 2 diabetes involving pro-inflammatory cytokines such as tumor necrosis factor and interleukin-6, insulin resistance, deranged fatty acid metabolism, and cellular processes such as mitochondrial dysfunction and endoplasmic reticulum stress. Improved understanding of obesity’s heterogeneity, including inter-individual differences in pathogenesis, propensity to regain lost weight, development of obesity-related complications including diabetes, and response to therapy, is critical to advance the development of effective and cost-effective interventions. In this review, the association between obesity with diabetes is highlighted.

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	JPR Solutions

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