Journal: Drug Invention Today

Article Id: JPRS-P col-00003346
Title: Association of obesity and type 2 diabetes
Category: Pharmaceutics
Section: Review Article
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    Globally, the prevalence of chronic non-communicable diseases is increasing at an alarming rate, propelling the upsurge in cases of diabetes is the growing prevalence of obesity. Most patients who are type 2 diabetic are obese, and the global epidemic of obesity largely explains the dramatic increase in the incidence and prevalence of type 2 diabetes over the past 20 years. Improved understanding will help advance identification and development of effective treatment options and how future research in these areas might be directed to benefit prevention, interventions, and overall patient care. Recent studies have identified “links” between obesity and type 2 diabetes involving pro-inflammatory cytokines such as tumor necrosis factor and interleukin-6, insulin resistance, deranged fatty acid metabolism, and cellular processes such as mitochondrial dysfunction and endoplasmic reticulum stress. Improved understanding of obesity’s heterogeneity, including inter-individual differences in pathogenesis, propensity to regain lost weight, development of obesity-related complications including diabetes, and response to therapy, is critical to advance the development of effective and cost-effective interventions. In this review, the association between obesity with diabetes is highlighted.

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    Author(s) Name:

    T. Akshay Satwik1 , Anitha Roy1 , R. Sarah Sathiyawathie2 *

    Affiliation(s) Name:

    1 Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India,

    2 Department of Research, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    *Corresponding author: R. Sarah Sathiyawathie, Department of Research, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    T. Akshay Satwik1 , Anitha Roy1 , R. Sarah Sathiyawathie2 *

    Title:Association of obesity and type 2 diabetes
    Journal:Drug Invention Today
    Vol(issue):11 (April)
    Year:2019
    Page No: (849-853)
  • Experimental Methods Keywords

    Methodology:Association, Diabetes, Insulin resistance, Obesity, Pathogenesis
    Research Materials:Type 2 diabetes

Keywords

Association Diabetes Insulin resistance Obesity Pathogenesis

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