Journal: Drug Invention Today
Title: In vitro antioxidant potential of acyclic isoprenoid isolated from Semecarpus anacardium
Category: Drugs from Plants
Section: Research Article
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Abstract
The present study was aimed to examine the in vitro antioxidant potential of acyclic isoprenoid isolated from Semecarpus anacardium seeds by different in vitro methods. The antioxidant activity was determined by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) activity, lipid peroxidation, nitric oxide, and hydroxyl radicals scavenging activity. Ascorbic acid was used as a standard antioxidant drug. The acyclic isoprenoid was used at 30, 60, 125.250, 500, and 1000 mg/ml concentrations and radical scavenging activity was determined in terms of inhibition percentage. Results revealed that acyclic isoprenoid inhibited the DPPH, lipid peroxide, nitric oxide, and hydroxyl radicals in a dose-dependent manner but pronounced radicals inhibitory effect was found at the concentration of 1000 µg/ml, and these inhibitory effects were less than that of ascorbic acid – used as a reference drug. This study revealed that the acyclic isoprenoid has significant antioxidant activity which might be helpful in preventing the progress of various oxidative stresses.
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Author(s) Name: Sundaram Ramalingam1*, Muthu Karuppiah2, Sivakumar Mullaivanam Ramasamy3, Ganesh Vasu4, Rahul Gopalakrishnan5, Shanthi Sivakumar6, V Vishnupriya7
Affiliation(s) Name: 1,7 Department of Biochemistry, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed University), Chennai, Tamil Nadu, India,
2 Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India,
3,6 Department of Zoology, University of Madras, Chennai, Tamil Nadu, India,
4,5 Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University, Dental Campus), Chennai, Tamil Nadu, India
*Corresponding author: Sundaram Ramalingam, Department of Biochemistry, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed University), Chennai - 600 077, Tamil Nadu, India.
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Author: Sundaram Ramalingam1*, Muthu Karuppiah2, Sivakumar Mullaivanam Ramasamy3, Ganesh Vasu4, Rahul Gopalakrishnan5, Shanthi Sivakumar6, V Vishnupriya7
Title: In vitro antioxidant potential of acyclic isoprenoid isolated from Semecarpus anacardium Journal: Drug Invention Today Vol(issue): 11 (April) Year: 2019 Page No: (928-932) -
Experimental Methods Keywords
Methodology: Acyclic isoprenoid, Antioxidant, Lipid peroxidation, Nitric oxide Research Materials: Semecarpus anacardium
Keywords
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