Journal: Drug Invention Today

Article Id: JPRS-DFP-00003365
Title: In vitro antioxidant potential of acyclic isoprenoid isolated from Semecarpus anacardium
Category: Drugs from Plants
Section: Research Article
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    The present study was aimed to examine the in vitro antioxidant potential of acyclic isoprenoid isolated from Semecarpus anacardium seeds by different in vitro methods. The antioxidant activity was determined by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) activity, lipid peroxidation, nitric oxide, and hydroxyl radicals scavenging activity. Ascorbic acid was used as a standard antioxidant drug. The acyclic isoprenoid was used at 30, 60, 125.250, 500, and 1000 mg/ml concentrations and radical scavenging activity was determined in terms of inhibition percentage. Results revealed that acyclic isoprenoid inhibited the DPPH, lipid peroxide, nitric oxide, and hydroxyl radicals in a dose-dependent manner but pronounced radicals inhibitory effect was found at the concentration of 1000 µg/ml, and these inhibitory effects were less than that of ascorbic acid – used as a reference drug. This study revealed that the acyclic isoprenoid has significant antioxidant activity which might be helpful in preventing the progress of various oxidative stresses.

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    Author(s) Name:

    Sundaram Ramalingam1*, Muthu Karuppiah2, Sivakumar Mullaivanam Ramasamy3, Ganesh Vasu4, Rahul Gopalakrishnan5, Shanthi Sivakumar6, V Vishnupriya7

    Affiliation(s) Name:

    1,7 Department of Biochemistry, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed University), Chennai, Tamil Nadu, India,

    2 Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India,

    3,6 Department of Zoology, University of Madras, Chennai, Tamil Nadu, India,

    4,5 Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University, Dental Campus), Chennai, Tamil Nadu, India

    *Corresponding author: Sundaram Ramalingam, Department of Biochemistry, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (Deemed University), Chennai - 600 077, Tamil Nadu, India.

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    Author:

    Sundaram Ramalingam1*, Muthu Karuppiah2, Sivakumar Mullaivanam Ramasamy3, Ganesh Vasu4, Rahul Gopalakrishnan5, Shanthi Sivakumar6, V Vishnupriya7

    Title:In vitro antioxidant potential of acyclic isoprenoid isolated from Semecarpus anacardium
    Journal:Drug Invention Today
    Vol(issue):11 (April)
    Year:2019
    Page No: (928-932)
  • Experimental Methods Keywords

    Methodology:Acyclic isoprenoid, Antioxidant, Lipid peroxidation, Nitric oxide
    Research Materials:Semecarpus anacardium

Keywords

1-Diphenyl-2-picrylhydrazyl Acyclic isoprenoid Antioxidant Lipid peroxidation Nitric oxide Semecarpus anacardium

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