Journal: Drug Invention Today

Article Id: JPRS-P col-00003369
Title: Association between anemia of inflammation and hematological parameters of aggressive periodontitis
Category: Pharmaceutics
Section: Research Article
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    Introduction: Anemia of inflammation formerly also called anemia of chronic disease, a cytokine-mediated anemia is a frequent complication of many inflammatory conditions or neoplastic disorders which are not due to decreased action of bone marrow or other diseases. It occurs despite the presence of adequate iron stored and vitamins. Periodontitis is an inflammatory disease of the periodontal tissues (the supporting tissues of the tooth) caused by specific microorganisms. Periodontal infections most often involve anaerobes such as Treponema denticola and Porphyromonas gingivalis. Studies show that reduced hemoglobin levels, erythrocyte counts, and increased white blood cells count are observed in patients with chronic generalized periodontitis, suggesting that this condition may be associated with anemia of chronic disease. This study was an attempt to determine the association between anemia of inflammation and the blood parameters of patients with aggressive periodontitis. Materials and Methods: Patients were selected from those attending the outpatient department of Saveetha Dental College and Hospitals and divided into two groups. Informed consent was obtained from the patient before sample collection. 3 ml of venous blood was collected and distributed in ethylenediaminetetraacetic acid collection tubes and centrifuged in 3000 rpm for serum. Then, serum was separated and analyzed by Mindray Hematology Analyzer for erythrocyte count, hemoglobin, leukocyte count, mean corpuscular volume, mean corpuscular hemoglobin concentration (MCHC), erythrocyte sedimentation rate, and packed cell volume (PCV). Conclusion: The present study showed that periodontal inflammation results in a decrease in a number of erythrocytes and levels of hemoglobin. This implies that aggressive periodontitis like other chronic conditions may lead to anemia. This anemia is mild to moderate, and inflammatory cytokines may also play a role in its pathogenesis.

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    Author(s) Name:

    P. S. Samyuktha, R. Gayatri Devi*, A. Jyothipriya

    Affiliation(s) Name:

    Department of Physiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gayatri Devi, Department of Physiology, Saveetha Dental College, Saveetha Institute of  Technical and Medical Science, Saveetha University, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    P. S. Samyuktha, R. Gayatri Devi*, A. Jyothipriya

    Title:Association between anemia of inflammation and hematological parameters of aggressive periodontitis
    Journal:Drug Invention Today
    Vol(issue):11 (April)
    Year:2019
    Page No: (941-944)
  • Experimental Methods Keywords

    Methodology:Aggressive periodontitis, Anemia of inflammation, Diagnosis, Gingiva, Hematology
    Research Materials:Outpatient

Keywords

Aggressive periodontitis Anemia of inflammation Diagnosis Gingiva Hematology

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