Journal: Drug Invention Today

Article Id: JPRS-P col-00003370
Title: Cytotoxic potential of Ocimum basilicum seed extract on human epidermoid carcinoma (KB cell lines) – An in vitro study
Category: Pharmaceutics
Section: Research Article
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    Background: Cancer, till today, remains on the unsolved mystery in the phase of prognosis. The death rate of this disease has been increasing in both developing and developed countries. Various researchers are working on the cure for this disease without any side effects. Hence, this study is aimed at to analyze the cytotoxic potential of Ocimum basilicum (OB) seed extract on oral carcinoma KB cell lines. Materials and Methods: KB Cell line: KB cell line was procured from NNSCCS, Pune and maintained in Dulbecco’s Modified Eagle Medium (DMEM). Preparation of test drug: OB seed was uniformly grinded and serially extracted in methanol, using Soxhlet apparatus. Cytotoxic assay: Cytotoxicity of OB seed was analyzed by 3-(4, 5dimethythiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay and compared with standard drug cisplatin. Results: The aqueous extract of OB has exhibited significant cytotoxic potential against oral cancer cell line. Conclusion: Aqueous extract of OB was effective as an antiproliferative agent which causes apoptosis in the oral cancer cell line.

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    Author(s) Name:

    Amanthi Ganapathy1 , R. Gayathri 2 *, V.Vishnu Priya2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gayathri, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 160, Poonamallee High Road, Chennai–600 077, Tamil Nadu, India.

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    Author:

    Amanthi Ganapathy1 , R. Gayathri 2 *, V.Vishnu Priya2

    Title:Cytotoxic potential of Ocimum basilicum seed extract on human epidermoid carcinoma (KB cell lines) – An in vitro study
    Journal:Drug Invention Today
    Vol(issue):11 (April)
    Year:2019
    Page No: (945-948)
  • Experimental Methods Keywords

    Methodology:Cytotoxic potential, KB cell line
    Research Materials:Ocimum basilicum

Keywords

Cytotoxic potential KB cell line Natural Ocimum basilicum

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