Journal: Drug Invention Today

Article Id: JPRS-P col-00003400
Title: Upregulation of alpha-1 receptor gene expression in benign prostate hyperplasia patients receiving long-term alpha-blocker therapy
Category: Pharmaceutics
Section: Research Article
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    Background: Benign prostate hyperplasia (BPH) is the most common degenerative disease in elderly men, with the alpha-1 blocker as the primary treatment. Long-term use of alpha-1 blocker, however, commonly leads to upregulation of alpha receptors and reduces the efficacy of treatment. Aim: This study aimed to find mRNA expression markers of upregulation and prostate contractility in BPH patients with a history of long-term alpha-1 blocker therapy. Methods: Prostate chips were obtained from 30 BPH patients with either no history of tamsulosin therapy, a history of tamsulosin 0.4 mg treatment therapy for 1 month and a history of tamsulosin 0.4 mg treatment therapy for >6 months with a histopathology result showing BPH. Organ bath instruments were used to measure isometric contractions of prostate smooth muscle, and real-time polymerase chain reaction was used to assess the number of adrenergic-α1 receptors. Results: Tamsulosin 0.4 mg therapy for 1 month decreased prostate smooth muscle contractility and significantly decreased mRNA expression compared to the group with no therapy. Tamsulosin 0.4 mg therapy for >6 months significantly increased mRNA expression and prostate smooth muscle contractility compared to the group with tamsulosin 0.4 mg therapy for 1 month. There were no significant differences in mRNA expression and prostate contractility in a group with 6 months of tamsulosin therapy compared to the group without tamsulosin therapy. Conclusion: Tamsulosin 0.4 mg therapy for >6 months led to upregulation marked by significantly increased in mRNA expression and prostate smooth muscle contractility.

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    Author(s) Name:

    Besut Daryanto1 *, Mulyohadi Ali 2 , Basuki Bambang Purnomo1 , Karyono Mintaroem3

    Affiliation(s) Name:

    1 Department of Urology, Faculty of Medicine, University of Brawijaya, Malang 65145, Indonesia,

    2 Department of Pharmacology, Faculty of Medicine, University of Brawijaya, Malang 65145, Indonesia,

    3 Department of Pathology Anatomy, Faculty of Medicine, University of Brawijaya, Malang 65145, Indonesia

    *Corresponding author: Besut Daryanto, Department of Urology, Faculty of Medicine, University of Brawijaya, Malang 65145, Indonesia.

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    Author:

    Besut Daryanto1 *, Mulyohadi Ali 2 , Basuki Bambang Purnomo1 , Karyono Mintaroem3

    Title:Upregulation of alpha-1 receptor gene expression in benign prostate hyperplasia patients receiving long-term alpha-blocker therapy
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (657-662)
  • Experimental Methods Keywords

    Methodology:Benign prostate hyperplasia, mRNA expression, Prostrate, Tamsulosin
    Research Materials:Prostate hyperplasia patients

Keywords

Benign prostate hyperplasia mRNA expression Prostrate Tamsulosin

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