Journal: Drug Invention Today

Article Id: JPRS-P col-00003402
Title: Characteristics and antioxidant activities of anthocyanin fraction in red dragon fruit peels (Hylocereus polyrhizus) extract
Category: Pharmaceutics
Section: Research Article
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    Background: Dragon fruit has been reported for its high antiradical activities with the presence of phenolic compounds. Some significant characteristics of plant pigment are betacyanin, anthocyanins, and other flavonoids. This study aimed to determine the anthocyanin components, antioxidant activity, and Total phenolic content (TPC) of anthocyanin from the extract of red dragon fruit peels. Materials and Methods: The research was used methanol extraction, followed by other analyses, and thin-layer chromatography (TLC) to obtain the fractionated components. Anthocyanins were analyzed with a liquid chromatography-mass spectrometry (LC-MS) instrument to obtain cyanidin, malvidin, and delphinidin. Total phenolic content of anthocyanin was measured with Folin-Ciocaltau. Results: Antioxidant activity revealed 56.68% (crude extract), 36.91% (F3), and 36.24% (F9). This study used TLC followed by column chromatography for better separation of phenolics. Among the three samples, the highest radical scavenging activity demonstrated by lethal concentration50 was the crude extract, followed by F3 and F9. The LC-MS assay identified the single types of phenolic compounds such as cyaniding (31.63%), malvidin (7.37%), and delphinidin (7.53%). Conclusions: Red dragon fruit peel extract (Hylocereus polyrhizus) containing phytochemical compounds is an effective antioxidant from natural plant sources, with anticarcinogenic and anti-inflammation properties, and may help with other degenerative disorders.

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    Author(s) Name:

    Imam Prabowo1 *, Edi Priyo Utomo2 , Agung Nurfaizy2 , Aris Widodo3 , Edi Widjajanto4 , Puji Rahadju5

    Affiliation(s) Name:

    1 Department of Ear, Nose, and Throat Head and Neck Surgery, Faculty of Medicine, Sebelas Maret University, Surakarta 57126, Central Java, Indonesia,

    2 Department of Chemistry, Faculty of Mathematic and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia,

    3 Department of Pharmacy, Faculty of Medicine, University Brawijaya, Malang 65145, Indonesia,

    4 Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang 65145, East Java, Indonesia,

    5 Department of Ear, Nose, and Throat Head and Neck Surgery, Faculty of Medicine, Brawijaya University, Malang 65145, East Java, Indonesia

    *Corresponding author: Imam Prabowo, Department of Ear, Nose, and Throat Head and Neck Surgery, Faculty of Medicine, Sebelas Maret University, Surakarta, Central Java, Indonesia.

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    Author:

    Imam Prabowo1 *, Edi Priyo Utomo2 , Agung Nurfaizy2 , Aris Widodo3 , Edi Widjajanto4 , Puji Rahadju5

    Title:Characteristics and antioxidant activities of anthocyanin fraction in red dragon fruit peels (Hylocereus polyrhizus) extract
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (670-678)
  • Experimental Methods Keywords

    Methodology: Antioxidant activities, Column chromatography, Fraction red dragon fruit (Hylocereus polyrhizus), Phenolic compound
    Research Materials:Red dragon fruit peels (Hylocereus polyrhizus) extract

Keywords

Anthocyanins Antioxidant activities Column chromatography Fraction red dragon fruit (Hylocereus polyrhizus) Phenolic compound

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