Journal: Drug Invention Today

Article Id: JPRS-P col-00003403
Title: Association of angiopoietin-2 level and vascular endothelial growth factor level with dengue infection severity in children
Category: Pharmaceutics
Section: Research Article
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    Aim: This study aimed to determine the association of angiopoietin-2 (ANGPT-2) and vascular endothelial growth factor (VEGF) level with dengue infection severity in children. Methods: This study was observational method with cross-sectional study in 108 infected dengue children in M. Djamil Hospital, Padang. Level of ANGPT-2 and VEGF was examined by enzyme-linked immunosorbent assay (ELISA) using Human ANGPT-2 and VEGF ELISA Kit, Ray Biotech. Statistical analysis consisted of descriptive and comparative analyses. Results: The results showed an increase in ANGPT-2 levels according to the severity of the disease in pediatric patients with dengue infection, and the difference was statistically significant (P < 0.05). While VEGF levels did not differ significantly between groups. Conclusion: Angiopoietin-2 plays a significant role in plasma leakage in patients with dengue virus infection. Levels of angiopoietin-2 significantly increased along with the severity of the disease. The increasing of VEGF has no association with the severity of dengue virus infection.

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    Author(s) Name:

    Mayetti Mayetti*, Ari Jamsari, Eryati Darwin, Dadang Hudaya Somasetia

    Affiliation(s) Name:

    Department of Pediatrics, Faculty of Medicine, Andalas University, Padang, Indonesia.

    *Corresponding author: Mayetti Mayetti, Jl. Teratai No. 4 Flamboyan, Padang, West Sumatera, Indonesia.

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    Author:

    Mayetti Mayetti*, Ari Jamsari, Eryati Darwin, Dadang Hudaya Somasetia

    Title:Association of angiopoietin-2 level and vascular endothelial growth factor level with dengue infection severity in children
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (679-683)
  • Experimental Methods Keywords

    Methodology:Angiopoietin-2, Children, Dengue infection, Vascular endothelial growth factor
    Research Materials:Dengue infection severity in children

Keywords

Angiopoietin-2 Children Dengue infection Vascular endothelial growth factor

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