Journal: Drug Invention Today

Article Id: JPRS-P col-00003435
Title: Studies on antimicrobial activity of Caesalpinia bonducella seed ethanolic extract on selected human oral pathogens
Category: Pharmaceutics
Section: Research Article
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    Background: Herbs have attracted attention as a potential natural health-care approach that focuses on protecting and restoring the health. Caesalpinia bonducella is an Indian herb reported in Ayurveda, the ancient medicine system of India. This plant have extensive uses in folk medicines for the treatment of a variety of diseases such as pneumonia and filarial infections. Objective: This study was aimed to assess the antimicrobial activity of ethanolic extract of C. bonducella seed in the oral pathogens of human. Materials and Methods: C. bonducella leaf ethanolic extract was used to identify the antibacterial activity. Then, the C. bonducella extract was dissolved in dimethyl sulfoxide to get 1 mg/ml concentration. After 50–200 ml volume of the C. bonducella leaf extract was loaded on to a sterile disc containing human oral pathogens respectively. Agar well diffusion method was used to determine the minimized inhibitory concentration. The antibacterial activity of C. bonducella was studied. After 24 h incubation, the plate was observed and the zone was measured for the calculation of minimum inhibitory concentration of the drug. The data were compared with respective pathogens. Result: In this study, C. bonducella leaf ethanolic extract dose-dependently increased the bacterial growth inhibition. However, 100% inhibition was observed against Enterococcus faecalis than the standard drug ciprofloxacin. Finally, the extract showed a potential antibacterial activity. Conclusion: The use of herbal medicine is increasing with an increase in the development of drug resistance among bacterial population. Herbal medicines are safe with no side effects and have significant action against bacteria and other microorganisms. Based on the results recorded in the present findings, it is concluded that C. bonducella has a potential antimicrobial agent on human oral pathogenic microorganisms, and hence, the herbal drug may serve as one of the potential antimicrobial agents.

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    Author(s) Name:

    C. Prathiba Reichal 1 , V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , M. Manikannan3 , J. Selvaraj1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India,

    3 Center for Drug Discovery and Development, Col. Dr. Jeppiaar Research Par, Sathyabama University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai–600 077, Tamil Nadu, India

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    Author:

    C. Prathiba Reichal 1 , V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , M. Manikannan3 , J. Selvaraj1 *

    Title:Studies on antimicrobial activity of Caesalpinia bonducella seed ethanolic extract on selected human oral pathogens
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (806-808)
  • Experimental Methods Keywords

    Methodology:Antimicrobial activity, Human pathogens
    Research Materials:Caesalpinia bonducella

Keywords

Antimicrobial activity Caesalpinia bonducella Human pathogens

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