Journal: Drug Invention Today

Article Id: JPRS-P col-00003442
Title: Antimicrobial activity of garlic extract on oral pathogens
Category: Pharmaceutics
Section: Research Article
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    Background: In the ancient time, many naturally occurring plants played an important role, in discovery in many therapeutic agents. It has been shown to have a beneficial role such as therapeutic uses which include beneficial effects on the cardiovascular system and antibiotic, anticancer, anti-inflammatory, and hypoglycemic effects. Garlic has major part. Garlic is also known as Allium sativum Linn. Human oral cavity has >500 species of bacteria of dental plague. Despite the garlic extract has been shown to have antimicrobial property, its effects of selected on human oral pathogens are yet to be identified. Objectives: The objectives of this study were to estimate the antimicrobial activity of garlic extraction on oral pathogens on Enterococci and Streptococcus mutans. Materials and Methods: Garlic extract will be proceeded from the local market and used for the present investigation. The extract will be mixed with distilled water 1 mg/ml concentration. Then, 10, 20, 30, 40, and 50 ml volume of extract will be loaded on agar well diffusion method to sterile discs with respective organisms of oral pathogens. Then, the antibacterial activity will be studied separately. After 24 h incubation period, the plates will be observed and inhibition zone was recorded as minimal inhibitory concentration. Results: The investigation of antibacterial activity of garlic extract Gram-positive bacteria such as against Entrococci and S. mutans was done by agar well diffusion method. Mean zones of inhibition of different concentrations were measured and compared with the control. In this study, garlic extract dose dependently increased the bacterial growth inhibition. However, 100% inhibition was observed against Entrococci and S. mutans than the standard drug ciprofloxacin. Finally, the extract showed a potential antibacterial activity. Conclusion: Based on the results recorded in the present findings, it was concluded that garlic extract has a potential antimicrobial agent on human oral pathogenic microorganisms, and hence, the herbal drug may serve as one of the potential antimicrobial agents.

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    Author(s) Name:

    K. S. Vikraman1 , V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , M. Manikannan3 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India,

    3 Center for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama University, Chennai, Tamil Nadu, India

    *Corresponding author: J. Selvaraj, Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.

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    Author:

    K. S. Vikraman1 , V. Vishnu Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , M. Manikannan3 , J. Selvaraj 1 *

    Title:Antimicrobial activity of garlic extract on oral pathogens
    Journal:Drug Invention Today
    Vol(issue):12 (April)
    Year:2019
    Page No: (831-833)
  • Experimental Methods Keywords

    Methodology:Antimicrobial activity ,Agar, Bacterial growth, Enterococci,Streptococcus mutans
    Research Materials:Garlic extract

Keywords

Agar Bacterial growth Enterococci Garlic extract Streptococcus mutans

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