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Abstract

Background: In the ancient time, many naturally occurring plants played an important role, in discovery in many therapeutic agents. It has been shown to have a beneficial role such as therapeutic uses which include beneficial effects on the cardiovascular system and antibiotic, anticancer, anti-inflammatory, and hypoglycemic effects. Garlic has major part. Garlic is also known as Allium sativum Linn. Human oral cavity has >500 species of bacteria of dental plague. Despite the garlic extract has been shown to have antimicrobial property, its effects of selected on human oral pathogens are yet to be identified. Objectives: The objectives of this study were to estimate the antimicrobial activity of garlic extraction on oral pathogens on Enterococci and Streptococcus mutans. Materials and Methods: Garlic extract will be proceeded from the local market and used for the present investigation. The extract will be mixed with distilled water 1 mg/ml concentration. Then, 10, 20, 30, 40, and 50 ml volume of extract will be loaded on agar well diffusion method to sterile discs with respective organisms of oral pathogens. Then, the antibacterial activity will be studied separately. After 24 h incubation period, the plates will be observed and inhibition zone was recorded as minimal inhibitory concentration. Results: The investigation of antibacterial activity of garlic extract Gram-positive bacteria such as against Entrococci and S. mutans was done by agar well diffusion method. Mean zones of inhibition of different concentrations were measured and compared with the control. In this study, garlic extract dose dependently increased the bacterial growth inhibition. However, 100% inhibition was observed against Entrococci and S. mutans than the standard drug ciprofloxacin. Finally, the extract showed a potential antibacterial activity. Conclusion: Based on the results recorded in the present findings, it was concluded that garlic extract has a potential antimicrobial agent on human oral pathogenic microorganisms, and hence, the herbal drug may serve as one of the potential antimicrobial agents.

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	JPR Solutions

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