Journal: Drug Invention Today
Title: Flavonoids used in the treatment of malignancy – A review
Category: Pharmaceutics
Section: Research Article
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Abstract
The aim of the review is to give an insight into the role of flavonoids in the treatment of malignancy. Flavonoids (or bioflavonoids) are a class of plant and fungus secondary metabolites. Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and heterocyclic ring (C). This carbon structure can be abbreviated C6-C3-C6. Other promising anticancer agents include flavopiridol, roscovitine, combretastatin A-4, betulinic acid, and silvestrol. From this list, one can well imagine the predominance of polyphenols, flavonoids and their synthetic analogs in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer. The role of flavonoids also includes the inhibition of activation of pro-carcinogens, inhibition of proliferation of cancer cells, selective death of cancer cells by apoptosis, inhibition of metastasis and angiogenesis, activation of the immune response against cancer cells, and modulation of the inflammatory cascade.
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About the authors and Affiliations
Author(s) Name: V. Lavanya1 , Dhanraj Ganapathy2 *, R. M. Visalakshi 2
Affiliation(s) Name: 1 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,
2 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
*Corresponding author: Dr. Dhanraj Ganapathy, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, 162, Poonamallee High Road, Chennai – 600 077, Tamil Nadu, India.
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Author: V. Lavanya1 , Dhanraj Ganapathy2 *, R. M. Visalakshi 2
Title: Flavonoids used in the treatment of malignancy – A review Journal: Drug Invention Today Vol(issue): 12 (May) Year: 2019 Page No: (1082-1085) -
Experimental Methods Keywords
Methodology: Cancer,Malignancy, Proliferation and Treatment Research Materials: Flavonoids
Keywords
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