Journal: Journal of Pharmacy Research
Title: Formulation and Evaluation of Taste masked Fast Dissolving Tablets of Ondansetron Hcl
Category: Pharmaceutics
Section: Research Article
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Abstract
During the last decade, the demand for mouth dissolving tablets has been growing, especially for geriatric and pediatric patients because of swallowing difficulties. Ondansetron Hcl as the model drug is a serotonin receptor (5- HT3) antagonist used in the prevention of chemotherapy induced nausea and vomiting. In this present study, the bitter taste of Ondansetron Hcl was masked using drug: Indion 204 in different ratios (1:1–1:3) and drug: eudragit E 100 in different ratios (1:1–1:4). For taste masking the ratio of drug: Indion 204 and drug: eudragit E 100 were optimized to 1:2 and 1:4 respectively by time intensity method. The FTIR studies showed drug and carrier were compatible. These were then compressed into tablets by direct compression method with using different superdisintegrants like Indion 414 in 1%, 1.5% and 2% concentration and croscarmellose sodium in 2%, 3% and 4% concentration. All formulations were evaluated for disintegration time, wetting time, weight variation, percentage friability and in vitro dissolution rate. Formulations with 2% Indion 414 and drug: Indion 204 in 1:2 ratio (DR6) and with 2% Indion 414 and drug: eudragit E 100 in 1:4 ratio (DE6) showed the disintegration time 10 seconds, 15 seconds and wetting time 30 seconds, 33 seconds respectively. In vitro dissolution studies of both formulations showed more than 90% drug released within 15 minutes. In vitro release profile, disintegration time and wetting time were remaining unchanged after two months when stored at 250C / 60% RH and at 400C / 75% RH.
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About the authors and Affiliations
Author(s) Name: R.Margret chandira*1, Debjit Bhowmik1, B.S Venkataeswarlu1, M.V..Kumudhavalli1 and Dr.B.Jayakar
Affiliation(s) Name: 1Vinayaka Missions College of pharmacy,Vinayaka missions university,Salem-636008,Tamilnadu ,India.
For correspondence:R.Margret chandira,
Vinayaka Missions College of pharmacy,Vinayaka missions
university,Salem-636008 ,Tamilnadu,India.
Email-debjit_cr@yahoo.com
Received on: 29-08-2008; Accepted on :10-09-2008-
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Author: R.Margret chandira*1, Debjit Bhowmik1, B.S Venkataeswarlu1, M.V..Kumudhavalli1 and Dr.B.Jayakar
Title: Formulation and Evaluation of Taste masked Fast Dissolving Tablets of Ondansetron Hcl Journal: Journal of Pharmacy Research Vol(issue): 1 (Oct-December 2008) Year: 2008 Page No: (200-207) -
Experimental Methods Keywords
Methodology: Formulation and Evaluation Research Materials: Tablets of Ondansetron Hcl
Keywords
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