Journal: Drug Invention Today

Article Id: JPRS-P col-00003633
Title: The effect of cranberry fruit extract on alpha -synuclein protein expression using immunostaining techniques
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of the study was to identify the neuroprotective effect of cranberry fruit extract by reducing the release of this biomarker by immunostaining techniques. Objective: The present study is to find out the alpha-lipoic acid cranberry fruit extract on alpha-synuclein protein expression using immunostaining techniques. Materials and Methods: The neuroblastoma SH-SY5Y cells were cultured and treated with various concentrations of cranberry fruit extract and were incubated with primary antibody alpha-synuclein and the antigen-antibody activity was visualized under a light microscope, and the results were quantified using image analysis software. Results: The study infers that when cranberry extract is added to the neurotoxic cell lines, the antigen-antibody reaction is interfered and as the concentration of cranberry fruit extract increases the corresponding decrease in the expression of the alpha-synuclein protein can be seen. Conclusion: Cranberry fruit extract proves to effectively reduce the expression of alpha-synuclein protein in neurotoxic cell lines so further research must be conducted in this field to discover the useful effects of cranberry so that it can be used as a neuroprotective agent in medicines to treat neurodegenerative disorders.

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    Author(s) Name:

    J. Sarvesh Kumar, V. Vishnu Priya*, R. Gayathri

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    J. Sarvesh Kumar, V. Vishnu Priya*, R. Gayathri

    Title:The effect of cranberry fruit extract on alpha -synuclein protein expression using immunostaining techniques
    Journal:Drug Invention Today
    Vol(issue):11 (June )
    Year:2019
    Page No: (1506-1508)
  • Experimental Methods Keywords

    Methodology:Neuroblastoma cells, Neuroprotective
    Research Materials:Cranberry extract

Keywords

Cranberry extract Neuroblastoma cells Neuroprotective

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