Journal: Drug Invention Today

Article Id: JPRS-P col-00003646
Title: In vitro anti-inflammatory activity of Trichosanthes cucumerina fruits
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of this study was to evaluvate the in vitro anti-inflammatory potential of Trichosanthes cucumerina fruits. Introduction: T. cucumerina (Family: Cucurbitaceae) is reported to show properties such as antidiabetic, antihelmintic, antifebrile, gastroprotective, and antioxidant effects. Inflammation is an adaptive response to harmful stimuli. However it plays major role in the pathogenesis of various diseases. Materials and Methods: The anti-inflammatory activity of the ethanolic extract of T. cucumerina (TCE) was assessed by human red blood cell membrane stabilization and inhibition of albumin denaturation. Discussion: The TCE fruits inhibited the hypotonicity-induced red blood cell membrane lysis and albumin denaturation, which are the measures of anti-inflammatory activity, in a concentration-dependent manner. Conclusion: TCE has potent anti-inflammatory activity.

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    Author(s) Name:

    S. Blessy Pushparathna1 , S. Kavitha2 *, V. Vishnupriya2 , R. Gayathri 2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    *Corresponding author: S. Kavitha, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 160, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    S. Blessy Pushparathna1 , S. Kavitha2 *, V. Vishnupriya2 , R. Gayathri 2

    Title:In vitro anti-inflammatory activity of Trichosanthes cucumerina fruits
    Journal:Drug Invention Today
    Vol(issue):12 (June)
    Year:2019
    Page No: (1170-1172)
  • Experimental Methods Keywords

    Methodology:Albumin denaturation, Anti-inflammation, Human red blood cell membrane stabilization,
    Research Materials: Trichosanthes cucumerina fruits

Keywords

Albumin denaturation Anti-inflammation Human red blood cell membrane stabilization Trichosanthes cucumerina

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