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Abstract

The microbial etiology of periodontal disease has been the focus of researchers for a long time. The hunt for the pathogens of the periodontal diseases is underway for more than 100 years and endless up today. Despite the increasing knowledge about oral microbiota, we are not able to implicate any one particular organism that can be considered as a candidate pathogen. In fact, the term “candidate pathogen” has lost its steam with a myriad of microorganisms being incriminated from time to time. Many studies, the bacterial etiology of periodontitis has used either culture-based or targeted deoxyribonucleic acid approaches and so it is likely that pathogens remain unidentified. The arrival of 16S cloning and sequencing has facilitated identification of several uncultivable bacteria in the oral cavity. Periodontal diseases have been traditionally associated with anaerobic Gram-negative microbiota. However, improvements in sampling handling and culture media have revealed that Gram-positive anaerobes belonging to the genus Eubacterium can make up around half of microbiota in advance disease. The present review highlights some Gram-positive microorganisms known bacteria associated with periodontal destruction.

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	JPR Solutions

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