Journal: Drug Invention Today

Article Id: JPRS-P col-00003691
Title: Assessment of intracellular calcium ion levels in neuroblastoma cells on treatment with kaempferol
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background: The neuroblast is a primitive nerve cell which does not undergo further division as it is a postmitotic cell. After the migration phase, it develops into a neuron. Materials and Methods: Cell culture – SHSY5Y cells were cultured and maintained in a prescribed medium. Cell treatment – the cells were pretreated with different concentrations of kaempferol for 4 h and then incubated with MPP+ for 2 h. Results and Conclusion: The intracellular calcium was significantly decreased at different dose levels, respectively. Kaempferol exhibits the good neuroprotective effect against MPP+-induced toxicity to SHSY5Y cells, but it expresses the significant decrease in MPP+-induced calcium production. Kaempferol was found to be an effective neuroprotective agent.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Ritya Mary Jibu1 , V. Vishnu Priya2 , R. Gayathri 2 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai–600 077, Tamil Nadu, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Ritya Mary Jibu1 , V. Vishnu Priya2 , R. Gayathri 2 *

    Title:Assessment of intracellular calcium ion levels in neuroblastoma cells on treatment with kaempferol
    Journal:Drug Invention Today
    Vol(issue):12 (June)
    Year:2019
    Page No: (1323-1325)
  • Experimental Methods Keywords

    Methodology:Calcium ion levels, Neuroblast cells, Neuroblastoma, SHSY5Y cells.
    Research Materials: Kaempferol

Keywords

Calcium ion levels Kaempferol Neuroblast cells Neuroblastoma SHSY5Y cells.

Our Services

Most Downloaded List