Journal: Drug Invention Today

Article Id: JPRS-P col-00003767
Title: Urease inhibitory activities of silver nanoparticles of Andrographis echioides fruit extract against Helicobacter pylori
Category: Pharmaceutics
Section: Research Article
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    Background: Helicobacter pylori is a Gram-negative bacteria that enter the body and start living in the digestive tract and, as the years pass by, they form ulcers in stomach and small intestine. H. pylori attacks the lining of stomach and damages it due to which acid gets through it forming ulcer. Andrographis echioides is an annual herb which is present throughout South India. Compounds derived from plants have played an important role in the development of several clinically useful anticancer agents. Materials and Methods: Andrographis echioides fruit powder was extracted with methanol in a Soxhlet apparatus for 8–16 h and silver nanoparticles were prepared and treated with Helicobacter pylori with varying concentrations. Urease activity was determined and urease inhibition by the extract was calculated. Results and Conclusion: From the results it is evident that Andrographis echioides fruit extract can be used as an anti-ulcer and antibacterial agent.

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    Author(s) Name:

    Tahreem Fathima1 , V. Vishnu Priya2 , R. Gayathri 2 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: R. Gayathri, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India

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    Author:

    Tahreem Fathima1 , V. Vishnu Priya2 , R. Gayathri 2 *

    Title:Urease inhibitory activities of silver nanoparticles of Andrographis echioides fruit extract against Helicobacter pylori
    Journal:Drug Invention Today
    Vol(issue):12 (July)
    Year:2019
    Page No: (1375-1377)
  • Experimental Methods Keywords

    Methodology:Urease inhibitory activities
    Research Materials:Andrographis echioides

Keywords

Helicobacter pylori ulcer andrographis echioides

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