Journal: Drug Invention Today

Article Id: JPRS-P col-00003918
Title: Effect of Saraswatarishta on sleep deprivation induced behavioral changes in mice
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Objective: The study is aimed to assess the effect of Saraswatarishta (SA) on behavioral changes following 96 h of sleep deprivation in mice. Materials and Methods: The study was done in the Department of Physiology, Sri Lakshmi Narayana Medical College and Research Institute. Proper ethical clearance was obtained from the CPCSEA. Thirty-six Swiss albino mice weighing 15–30 g were used for the study. Results: The 36 Swiss albino mice were divided into three groups with six animals in each group: Group I – control-(6), Group II – sleep-deprived group, and Group III – SA treated sleep-deprived group. SA was administered orally in the dose of 1.8 ml/kg/day for 15 days. Following this, the animals were deprived of sleep for 96 h using flower pot technique. Behavior was assessed using open field maze and elevated plus maze. Statistical analysis was performed by one-way ANOVA using SPSS version 20 when compared to controls, mice that were deprived sleep showed behavioral changes. The immobilization time and the time spent in the closed arm were increased with a significant decrease in the ambulation. Whereas in the group treated with SA, the immobilization time and the time spent in the closed arm were decreased with an increase in the ambulation when compared with the sleep-deprived group not treated with SA. Sleep-deprived mice showed alteration in behavior when compared to controls.Conclusions: This study identified that SA treated group showed an improvement in such behavioral changes when compared to the sleep-deprived group not treated with SA. Hence, it proves that SA exerts antidepressant effects on its own on sleep-deprived rats.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    R. Yuvaraj 1 , R. Vijayakumar1 *, G. Bupesh2 , S. Vasanth2

    Affiliation(s) Name:

    1 Department of Physiology, Lakshmi Narayana Medical College and Research Institute, Pondicherry, India,

    2 R&D Wing, Central Research Laboratory, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. R. Vijayakumar, Department of Physiology, Lakshmi Narayana Medical College and Research Institute, Pondicherry, India

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    R. Yuvaraj 1 , R. Vijayakumar1 *, G. Bupesh2 , S. Vasanth2

    Title:Effect of Saraswatarishta on sleep deprivation induced behavioral changes in mice
    Journal:Drug Invention Today
    Vol(issue):12 (August )
    Year:2019
    Page No: (1741-1744)
  • Experimental Methods Keywords

    Methodology:Flower pot technique,Sleep deprivation
    Research Materials: Saraswatarishta

Keywords

Flower pot technique Saraswatarishta Sleep deprivation

Our Services

Most Downloaded List