Journal: Drug Invention Today
Title: Hepatocurative effects of methanol extract of Acanthus montanus leaves on acetaminophen-induced liver failure in rats
Category: Pharmaceutics
Section: Research Article
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Abstract
Objective: This study was designed to investigate hepatocurative activities of the methanol extract of Acanthus montanus leaves on acetaminophen-induced liver failure in rats. Materials and Methods: The acute toxicity and hepatocurative activities of the extract were studied using mice and Wistar albino rats, respectively. The rats were distributed into five groups of five rats each. Group 1 served as normal control while Goups 2–5 were acetaminophen-induced orally. Groups 2 and 3 served as negative and positive controls, respectively, while Groups 4 and 5 served as the hepatocurative groups. Liver failure in rats was induced with 2500 mg/kg body weight of acetaminophen administered orally. Group 3 was treated with silymarin, 100 mg/kg body weight whereas Groups 4 and 5 were treated with the extract, 200 and 500 mg/kg body weight of the methanol extract of A. montanus leaves, respectively. Results: The acute toxicity results on methanol extract of A. montanus leaves in mice showed that the extract caused no adverse reactions or death in the mice. Treatment of acetaminophen-induced liver failure in rats with the extract caused significantly (P < 0.05) reduction of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities, and total bilirubin concentrations and significantly (P < 0.05) increased total protein, albumin, direct bilirubin concentrations, and improved liver histomorphology that were negatively altered by acetaminophen toxicity. Conclusion: The findings of this study suggest that methanol extract of A. montanus leaves possesses hepatocurative activities capable of restoring liver failure and ameliorating adverse effects associated with hepatotoxicity.
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Author(s) Name: Uroko Robert Ikechukwu1 *, Chinedu Paulinus Nwuke1 , Nancy Oluomachi Uchenna1 , Chidimma Lilian Asadu2 , Emeka John Dingwoke3 , Fatima Amin Adamude4 , Nwobodo Ndubuisi Nwobodo5
Affiliation(s) Name: 1 Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria,
2 Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria,
3 Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna State, Nigeria,
4 Department of Biochemistry, Federal University Lafia, Nasarawa State, Nigeria,
5 Department of Pharmacology and Therapeutics, College of Medicine, Parklane Campus, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria
*Corresponding author: Uroko Robert Ikechukwu, Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.
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Author: Uroko Robert Ikechukwu1 *, Chinedu Paulinus Nwuke1 , Nancy Oluomachi Uchenna1 , Chidimma Lilian Asadu2 , Emeka John Dingwoke3 , Fatima Amin Adamude4 , Nwobodo Ndubuisi Nwobodo5
Title: Hepatocurative effects of methanol extract of Acanthus montanus leaves on acetaminophen-induced liver failure in rats Journal: Drug Invention Today Vol(issue): 11 (September ) Year: 2019 Page No: (2176-2183) -
Experimental Methods Keywords
Methodology: Hepatotoxicity, Histomorphology, liver functions, Liver marker enzymes Research Materials: Acanthus montanus
Keywords
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