Journal: Drug Invention Today

Article Id: JPRS-DFP-00003991
Title: Flavonoids from cell suspension culture of Ocimum tenuiflorum and its enhancement using response surface methodology
Category: Drugs from Plants
Section: Research Article
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    Ocimum tenuiflorum (Tulsi) is an aromatic shrub belonging to the basil family Lamiaceae and has been used in Indian traditional medicine. Various characteristics such as its antioxidant, anticancer, antiviral, antiallergic, antimicrobial, and anti- inflammatory activities are major reason to produce the phytochemicals in vitro. The current paper studied the enhancement of flavonoid in the plant cell suspension culture of O. tenuiflorum. Callus was initiated from leaf explant under optimized treatment of plant growth regulators. Effect of major factors such as precursors and elicitors on the synthesis of flavonoid in the suspension culture was studied. All the optimization studies were carried out with the help of Box–Behnken design of response surface methodology. Results indicated optimization of elicitors and precursors resulted in 2-fold increase in flavonoid synthesis. The generated results can be employed after the validation in upscaled operations for flavonoid production.

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    Author(s) Name:

    Anu Jacob, Jibu Thomas*

    Affiliation(s) Name:

    Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, India

    *Corresponding author: Jibu Thomas, Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore-641 114, Tamil Nadu, India.

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    Author:

    Anu Jacob, Jibu Thomas*

    Title:Flavonoids from cell suspension culture of Ocimum tenuiflorum and its enhancement using response surface methodology
    Journal:Drug Invention Today
    Vol(issue):11 (September )
    Year:2019
    Page No: (2188-2193)
  • Experimental Methods Keywords

    Methodology:response surface methodology, Optimization, Precursors
    Research Materials:Flavonoid, Ocimum tenuiflorum

Keywords

Elicitor Flavonoid Ocimum tenuiflorum Optimization Precursors

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