Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000403
Title: Development of promising fast dissolving tablets of Stiripentol: a novel antiepileptic drug
Category: Pharmaceutics
Section: Research Article
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    Stiripentol (STP) is a novel orphan drug which is used as adjunctive therapy for the treatment of severe myoclonic epilepsy in infancy (SMEI, Dravet syndrom). Due to sudden onset of epileptic attack, it is necessary to formulate antiepileptics into such a delivery system, which provides immediate relief. For elderly and pediatrics, dysphagia (difficulty in swallowing) is a common complain. Mouth dissolving tablets formalize an innovative dosage form that conquer the swallowing problems and provide a quick onset of action. The purpose of the present research work was to develop and optimize the formulation of fast dissolving tablets of Stiripentol. Fast dissolving tablets of Stiripentol were prepared by direct compression method using different types of superdisintegrants such as croscarmellose sodium and sodium starch glycolate. The powders were evaluated for angle of repose, compressibility index and hausner's ratio. The prepared tablet formulations were evaluated for hardness, friability, wetting time, drug content, disintegration, water absorption ratio, weight uniformity and the drug release. The results revealed that the formulation F9 which containing a combination of 6% sodium starch glycolate and 15% croscarmellose sodium as superdisintegrants has good dissolution profile and rapid release with shortest disintegration time. It can be concluded that the fast dissolving tablets of the poorly soluble drug, stiripentol, showed enhanced dissolution which could lead to improved its bioavailability and effectiveness.

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  • About the authors and Affiliations

    Author(s) Name:

    Samar A. Afifi

    Affiliation(s) Name:

    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Department of Pharmaceutics, National Organization for Drug Control and Research, Giza, Egypt

    *Corresponding author.
    Samar A. Afifi
    Department of Pharmaceutics,
    King Saud University, P. O. Box 22452,
    Riyadh 11495, Saudi Arabia

    Received on:09-05-2014; Accepted on:11-06-2014

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    Samar A. Afifi

    Title:Development of promising fast dissolving tablets of Stiripentol: a novel antiepileptic drug
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (June)
    Page No: (812-817)
  • Experimental Methods Keywords

    Methodology:fast dissolving tablets
    Research Materials:Stiripentol


Stiripentol fast dissolving tablets croscarmellose sodium sodium starch glycolate superdisintegrant

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