Journal: Drug Invention Today
Title: Antihyperglycemic and antioxidant effect of Allium sativum aqueous bulb extract against alloxan‑induced diabetic male albino rats
Category: Pharmaceutics
Section: Research Article
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Abstract
Herbal drugs play an important role in health programs worldwide and there is a resurgence of interest in herbal medicines for the treatment of various ailments including diabetes mellitus. In both insulin-dependent (Type 1) and non-insulin- dependent diabetes (Type 2), an increased oxidative stress has been notified. In the present study, the folklore medicinal plant Allium sativum was selected to evaluate its antihyperglycemic and antioxidant effect against alloxan-induced diabetic male albino rats. The biochemical parameters such as blood glucose, insulin, and lipid profile (cholesterol, triglycerides, high- density lipoprotein, low-density lipoprotein (LDL) and very LDL, urea, uric acid, and creatinine) were analyzed. Finally, the antioxidant parameters such as superoxide dismutase, catalase, glutathione peroxide, and glutathione S-transferase also analyzed. The aqueous extract shows very good antidiabetic activity confirmed by biochemical parameters and histopathological analysis.
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About the authors and Affiliations
Author(s) Name: S. Sureshkumar1 , B. Senthilkumar2 *, S. Rajeshkumar3 , M. Nangalingam1
Affiliation(s) Name: 1 Department of Biochemistry, Indo-American College, Cheyyar, Tamil Nadu, India,
2 Department of Zoology, Thiruvalluvar University, Vellore, Tamil Nadu, India,
3 Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
*Corresponding author: B. Senthilkumar, Department of Zoology, Thiruvalluvar University, Vellore, Tamil Nadu, India.
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Author: S. Sureshkumar1 , B. Senthilkumar2 *, S. Rajeshkumar3 , M. Nangalingam1
Title: Antihyperglycemic and antioxidant effect of Allium sativum aqueous bulb extract against alloxan‑induced diabetic male albino rats Journal: Drug Invention Today Vol(issue): 12 (September ) Year: 2019 Page No: (1965-1968) -
Experimental Methods Keywords
Methodology: Antihyperglycemic and antioxidant effect Research Materials: Allium sativum
Keywords
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