Journal: Drug Invention Today

Article Id: JPRS-P col-00004064
Title: Antihyperglycemic and antioxidant effect of Allium sativum aqueous bulb extract against alloxan‑induced diabetic male albino rats
Category: Pharmaceutics
Section: Research Article
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Herbal drugs play an important role in health programs worldwide and there is a resurgence of interest in herbal medicines for the treatment of various ailments including diabetes mellitus. In both insulin-dependent (Type 1) and non-insulin- dependent diabetes (Type 2), an increased oxidative stress has been notified. In the present study, the folklore medicinal plant Allium sativum was selected to evaluate its antihyperglycemic and antioxidant effect against alloxan-induced diabetic male albino rats. The biochemical parameters such as blood glucose, insulin, and lipid profile (cholesterol, triglycerides, high- density lipoprotein, low-density lipoprotein (LDL) and very LDL, urea, uric acid, and creatinine) were analyzed. Finally, the antioxidant parameters such as superoxide dismutase, catalase, glutathione peroxide, and glutathione S-transferase also analyzed. The aqueous extract shows very good antidiabetic activity confirmed by biochemical parameters and histopathological analysis.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    S. Sureshkumar1 , B. Senthilkumar2 *, S. Rajeshkumar3 , M. Nangalingam1

    Affiliation(s) Name:

    1 Department of Biochemistry, Indo-American College, Cheyyar, Tamil Nadu, India,

    2 Department of Zoology, Thiruvalluvar University, Vellore, Tamil Nadu, India,

    3 Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: B. Senthilkumar, Department of Zoology, Thiruvalluvar University, Vellore, Tamil Nadu, India.

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    S. Sureshkumar1 , B. Senthilkumar2 *, S. Rajeshkumar3 , M. Nangalingam1

    Title:Antihyperglycemic and antioxidant effect of Allium sativum aqueous bulb extract against alloxan‑induced diabetic male albino rats
    Journal:Drug Invention Today
    Vol(issue):12 (September )
    Year:2019
    Page No: (1965-1968)
  • Experimental Methods Keywords

    Methodology:Antihyperglycemic and antioxidant effect
    Research Materials:Allium sativum

Keywords

Allium sativum Alloxan Antioxidant Diabetes

Our Services

Most Downloaded List