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Abstract

Synthetic and natural polymers like gelatin, pectin, chitosan nanoparticles, pectin cisplatin conjugates have an established role as biomedical materials. Nanotechnology has made significant advances in the reduction of free radical damage in the field of materials science. Cross-disciplinary interactions and the application of this technology to biological systems has led to the elucidation of novel nanoparticle antioxidants, which are the subject of our study. Natural antioxidants, including vitamin E (a-tocopherol), vitamin C and others have the ability to potentially modulate oxidative stress. Oxidative stress has been implicated as a cause of cancer, arthritis, heart disease and even aging. Natural antioxidants are prone to degradation and their bioavailability is limited by low absorption and degradation during delivery. Nanoparticles can offer several advantages over traditional delivery methods for antioxidants, which include protection of the bioactive component from the environment, an increase in the bioavailability of the antioxidant targeted delivery of the component, as well as its controlled release at the site of action. Chitosan, a linear polysaccharide derived from chitin obtained from crustacean shells, has emerged as a useful drug delivery matrix because of it polycationic nature, biodegradability, biocompatibility, mucoadhesiveness and ease of physical and chemical modification. The use of nanoparticles as drug delivery vehicles for anticancer therapeutics has great potential to revolutionise the future of cancer therapy. Therefore, the present study has been undertaken to evaluate the in-vivo GST activity of chitosan nanoparticles specifically on the tissues of Balb/c mice.

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	JPR Solutions

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