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Abstract

Aim: The paper presents the results of a study of interrelationships of polymorphic cytokine loci (rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1 and rs1800469 TGFβ-1) with the features of glucocorticoid therapy in patients with chronic glomerulonephritis. Method: The study of therapy efficiency (medication with glucocorticoids, cytostatics, and angiotensin- converting enzyme inhibitors) was conducted among 169 patients with CGN (79 men and 90 women). The average age of patients was 36.2 ± 8.9 years; the duration of disease was 7.4 ± 5.6 years. In this research, homozygotes by pro-inflammatory and fibroblastic alleles were combined into one group with heterozygotes. Results and Discussion: The research materials were processed by statistical methods, using the program Statistica 8.0. The criterion cChi-square was applied with the aim to analyze the compliance of the observed distribution of genotypes with the expected, based on the Hardy– Weinberg equilibrium. In the process of comparative analysis of the frequencies of alleles and genotypes of the studied loci between the control and case groups of patients, the Chi-square criterion was used, with Yates correction for continuity. Conclusion: It has been established, that in patients with chronic glomerulonephritis, which have proinflammatory gene alleles of lymphotoxin α (rs909253) and the tumor necrosis factor receptor (rs767455), glucocorticoid therapy is not very effective (only 10-30% of these patients are steroid sensitive). In case of non-inflammatory alleles of these genes, the efficiency of hormone therapy is maximum: steroid-sensitive nephrotic syndrome is observed in 73-90% of patients (p <0.001).

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	JPR Solutions

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