Journal: Drug Invention Today

Article Id: JPRS-P col-00004126
Title: Patient with myelodysplastic syndrome and acute myelocytic leukemia at Dr. Soetomo General Hospital, Surabaya
Category: Pharmaceutics
Section: Research Article
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    Background: According to the World Health Organization, there are 250 cases of leukemia globally. The case fatality rate (CFR) is at 76%, for young/middle age, the CFR is 35–40%, and for age older than 60, it is 5–15%. The occurrence of acute myelocytic leukemia (AML) is 3.5/100,000 people per year, with a higher occurrence in men than in women (4.3 vs. 2.9, at the age of 67 years old). The incident of myelodysplastic syndrome (MDS) mostly occurs in people over the age of 70 years old and tends to turn into AML. The objective of this case report is to know the number of leukemia cases, especially AML and MDS cases that are based on gender and age. Methods: These data were gathered from 228 leukemia patients from a total of 434 visits. Incomplete exclusions were applied to 47 people with the age range of 14–77 years old, while the remaining 181 people formed the complete sample. The diagnoses of AML and MDS are based on the morphology of blood smear cell and hematology analysis. Results: In Surabaya, East Java, Indonesia, AML is found at 38.66% and MDS at 4.98% from 181 samples, with higher cases in women than men. Conclusion: In summary, patients with AML diagnosis were related to age; the highest risk of AML was found at the ages of 46–61 years (37.14%) from 70 people. There were four patients with an MDS diagnosis at the ages of 14–29 years, while there was only one older aged patient, aged 62–77 years old (11.1%), showing that the younger age group presents a higher risk. We hope future research will further observe new biomarkers to diagnose AML, MDS, and MDS-related AML.

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    Author(s) Name:

    Mulya Dinata1,2 , Pudji Rahayu3 , S. Ugroseno Yudho Bintoro4 *, Edi Widjajanto5

    Affiliation(s) Name:

    1 Doctoral Program of Medical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia,

    2 Department of Clinical Pathology, Faculty of Medicine, Widya Mandala Catholic University Surabaya, Indonesia,

    3 Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Brawijaya, Dr. Saiful Anwar General Hospital, Malang, Indonesia,

    4 Department of Internal Medicine, Division of Hematology and Medical Oncology, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia,

    5 Department of Clincal Pathology, Faculty of Medicine, Brawijaya University, Malang, Indonesia

    *Corresponding author: S. Ugroseno Yudho Bintoro, Department of Internal Medicine, Division of Hematology and Medical Oncology, Dr. Soetomo Teaching Hospital, Surabaya, Indonesia.

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    Author:

    Mulya Dinata1,2 , Pudji Rahayu3 , S. Ugroseno Yudho Bintoro4 *, Edi Widjajanto5

    Title:Patient with myelodysplastic syndrome and acute myelocytic leukemia at Dr. Soetomo General Hospital, Surabaya
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (2419-2422)
  • Experimental Methods Keywords

    Methodology: Acute myelocytic leukemia, Hematology, Incomplete exclusions, Leukemia, Myelodysplastic syndrome
    Research Materials:228 leukemia patients

Keywords

Acute myelocytic leukemia Hematology Incomplete exclusions Leukemia Myelodysplastic syndrome

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