Journal: Drug Invention Today

Article Id: JPRS-P col-00004127
Title: Comparison of visual field defect severity level between nonarteritic anterior ischemic optic neuropathy with and without metabolic syndrome
Category: Pharmaceutics
Section: Research Article
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    Background: Nonarteritic anterior ischemic optic neuropathy (NA-AION) is the second most common optic neuropathy in adults, with an incidence rate of 2.3–10.2/100,000 population/year in the US. Metabolic syndrome (MS) is known to be one systemic risk factor of NA-AION. This study aimed to determine the relationship between NA-AION and MS. Methods: This study use data from medical records from neuro-ophthalmology polyclinic in Dr. Saiful Anwar General Hospital from 2015 to 2017. Visual acuity (VA) established from Snellen chart examination, anterior segment from biomicroscopy examination, posterior segment from direct fundoscopy, and perimetry (geographic appearance of visual field defect and mean defect [MD]). Laboratory examination (MS component based on International Diabetes Federation 2006 consensus), waist circumference, blood pressure, height and weight, as well as patient with edema papil at neuro- ophthalmology outpatient clinic, in Dr. Saiful Anwar General Hospital, Malang. All data of NA-AION patients with and without MS were analyzed using SPSS 20.0 (Chi-square, Spearman correlation, and Mann–Whitney U-test). Results: This study involved 52 samples from medical record data where most subjects were in the age ranging of 41–60 years old, mean age 54 years, and no gender predominance. More than one-third (40.38%) of NA-AION patients experienced MS. The correlation between MS and perimetry MD value was weak (P = 0.322), Spearman correlation contingency coefficient of 0.251, and Mann–Whitney result sig. Z (0.612). The initial patient VA was 6/6–6/18. In this research, a mean waist circumference of 85.5 cm and body mass index of 26.5 (OW) were obtained. The bilateral attack, segmental edema of optic nerve hypoplasia, and altitudinal visual field defect with MD >12 dB were most dominant. Conclusion: About 40.38% of patient with NA-AON experienced MS, showing a weak correlation with no significant difference between the presence and absence of MS. No gender predominance was found. A multidisciplinary scientific approach is needed to identify the risk factors of NA-AION.

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    Author(s) Name:

    Seskoati Prayitnaningsih*, Devi Putri Swadayani

    Affiliation(s) Name:

    Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital, Malang, East Java, Indonesia

    *Corresponding author: Seskoati Prayitnaningsih, Department of Ophthalmology, University of Brawijaya, Saiful Anwar General Hospital, Malang 65145, East Java, Indonesia.

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    Seskoati Prayitnaningsih*, Devi Putri Swadayani

    Title:Comparison of visual field defect severity level between nonarteritic anterior ischemic optic neuropathy with and without metabolic syndrome
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Page No: (2423-2427)
  • Experimental Methods Keywords

    Methodology:International Diabetes Federation 2006, Metabolic syndrome, Nonarteritic anterior ischemic optic neuropathy, Waist circumference
    Research Materials:52 samples from medical record


International Diabetes Federation 2006 Metabolic syndrome Nonarteritic anterior ischemic optic neuropathy Waist circumference

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