Journal: Drug Invention Today

Article Id: JPRS-P col-00004128
Title: The effect of lutein and zeaxanthin administration on reactive oxygen species levels in blood serum and contrast sensitivity changes in patients with non-proliferative diabetic retinopathy
Category: Pharmaceutics
Section: Research Article
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    Background: Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus. The high levels of reactive oxygen species (ROS) in diabetes can cause pericyte loss and endothelial damage, which causes disturbances in visual function. This study aims to investigate the effect of lutein and zeaxanthin (L/Z) administration on ROS levels in blood serum and contrast sensitivity in patients with non-proliferative DR (NPDR). Materials and Methods: This study used a pre- and post-test control design. All subjects were NPDR patients. ROS levels in blood serum were measured using ELISA and contrast sensitivity was examined using the Pelli-Robson chart, before and after administration of 6 mg of lutein and 0.5 mg of zeaxanthin (Cendo-TGF®) for 30 days. Correlations were performed to examine the relationship between changes in ROS levels and contrast sensitivity. Results: The mean ROS level before L/Z administration was 15.512 ng/ml and was reduced to 6.707 ng/ml after L/Z administration (P < 0.05). The mean contrast sensitivity before L/Z administration was 1.286 and was increased to 1.425 (P < 0.05). There was a positive correlation between ROS serum level and contrast sensitivity, but this was not significant (P > 0.05). Conclusion: L/Z administration is able to decrease ROS levels in blood serum and increase contrast sensitivity scores in patients with NPDR. The reduction in ROS level is positively correlated with increasing contrast sensitivity score, but this correlation is not statistically significant.

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    Author(s) Name:

    Safaruddin Refa*, Catur Kurnia Wardhani, Nadia Artha Dewi

    Affiliation(s) Name:

    Department of Ophthalmology, Faculty of Medical Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia, East Java, Indonesia

    *Corresponding author : Safaruddin Refa, Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital Malang, East Java, Indonesia.

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    Author:

    Safaruddin Refa*, Catur Kurnia Wardhani, Nadia Artha Dewi

    Title:The effect of lutein and zeaxanthin administration on reactive oxygen species levels in blood serum and contrast sensitivity changes in patients with non-proliferative diabetic retinopathy
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (2428-2433)
  • Experimental Methods Keywords

    Methodology:Contrast sensitivity, Lutein, Non-proliferative diabetic retinopathy, Reactive oxygen species, Zeaxanthin
    Research Materials: lutein and zeaxanthin

Keywords

Contrast sensitivity Lutein Non-proliferative diabetic retinopathy Reactive oxygen species Zeaxanthin

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